CAJ | 학술논문

背景微小RNA(micmRNA,miRNA)是体内重要的基因水平调节物质,它能调控约1/3的人类蛋白编码基因表达.体内组织细胞缺氧后,miRNA水平发生变化,其中变化最显著的是微小RNA-210(microRNA-210,miR-210).目的由于miR-210易受低氧诱导,综述miR-210在低氧下的生物化学功能,并探讨其潜在的临床应用.内容概述miR-210在线粒体代谢、血管生成、DNA修复和细胞存活等方面的作用.趋向为miR-210相关疾病的诊疗提供参考.
배경 미소RNA(micmRNA,miRNA)시체내중요적기인수평조절물질,타능조공약1/3적인류단백편마기인표체.체내조직세포결양후,miRNA수평발생변화,기중변화최현저적시미소RNA-210(microRNA-210,miR-210).목적 유우miR-210역수저양유도,종술miR-210재저양하적생물화학공능,병탐토기잠재적림상응용.내용 개술miR-210재선립체대사、혈관생성、DNA수복화세포존활등방면적작용.추향 위miR-210상관질병적진료제공삼고.
Background MicroRNA(miRNA) is an important regulatory factor that can regulate approximately 30％ human protein-coding genes.The level of miRNA will be changed after the tissue under hypoxia,and the most significant change is of microRNA-210 (miR-210).Objective This review discusses the emerging biochemical functions of this miRNA and explores its potential clinical applications.Content Outline the role of miR-210 in mitochondrial respiration,arrest of DNA repair,vascularbiology and angiogenesis.Trend Provide references for the diagnosis and therapy of miR-210-related disorders.