CAJ | 학술논문

黄嘌呤氧化还原酶(XOR)通过将嘌呤分解为尿酸,控制着人体内嘌呤代谢的限速步骤.近年来研究表明XOR活性的异常不仅可导致高尿酸血症和痛风,还积极地参与了代谢综合征的发生、发展.XOR如何影响肥胖、高血压、动脉粥样硬化、糖尿病等代谢综合征相关疾病尚不明确,其可能机制包括调节脂质代谢转录调控因子,影响尿酸、一氧化氮及活性氧簇的生成等.XOR抑制剂如别嘌呤醇和非布索坦对上述疾病有一定的保护效果,这为代谢综合征的防治提供了新思路.
황표령양화환원매(XOR)통과장표령분해위뇨산,공제착인체내표령대사적한속보취.근년래연구표명XOR활성적이상불부가도치고뇨산혈증화통풍,환적겁지삼여료대사종합정적발생、발전.XOR여하영향비반、고혈압、동맥죽양경화、당뇨병등대사종합정상관질병상불명학,기가능궤제포괄조절지질대사전록조공인자,영향뇨산、일양화담급활성양족적생성등.XOR억제제여별표령순화비포색탄대상술질병유일정적보호효과,저위대사종합정적방치제공료신사로.
Xanthine oxidoreductase (XOR) controls the rate limiting step of purine catabolism by converting xanthine to uric acid.Recent studies showed that the abnormal activity of XOR not only led to hyperuricemia and gout,but also actively participated in the development of metabolic syndrome.However,how XOR affects obesity,hypertension,atherosclerosis,diabetes and other metabolic syndrome related diseases remains unclear.Its possible mechanism includes regulating the transcription factors of adipogenesis,affecting the synthesis of uric acid,nitric oxide and reactive oxygen species,etc.XOR inhibitor such as allopurinol and febuxostat has a protective effect of the diseases mentioned above.These findings would provide new ideas for treatment of metabolic syndrome.