CAJ | 학술논문

甲状腺激素(TH)对能量与脂代谢具有重要的调节作用.近年来,随着甲状腺激素受体(TR)亚型的发现,众多研究者对其在代谢调节中的功能进行了一系列研究.TR在人体各组织广泛存在,其中TRβ与TH结合后,能降低胆固醇与甘油三酯水平.目前,TRβ激动剂已作为新型降脂药进入临床研究,它可能通过逆向胆固醇转运及非胆汁性胆固醇排泄的通路达到降低血脂的效果.未来TR在降脂及减肥方面的前景日益得到广泛关注,它极有可能成为众多治疗脂代谢紊乱及相关疾病的新靶点.
갑상선격소(TH)대능량여지대사구유중요적조절작용.근년래,수착갑상선격소수체(TR)아형적발현,음다연구자대기재대사조절중적공능진행료일계렬연구.TR재인체각조직엄범존재,기중TRβ여TH결합후,능강저담고순여감유삼지수평.목전,TRβ격동제이작위신형강지약진입림상연구,타가능통과역향담고순전운급비담즙성담고순배설적통로체도강저혈지적효과.미래TR재강지급감비방면적전경일익득도엄범관주,타겁유가능성위음다치료지대사문란급상관질병적신파점.
Thyroid hormone (TH) plays a significant role in regulating both energy and lipid metabolism.Since the subtypes of thyroid hormone receptor (TR) have been explored and reported several years ago,numerous studies have been focused on their roles in metabolic regulation.TR can be extensively found in tissues of the human body.The binding of TH and TRβ can lower the levels of cholesterol and triglyceride.Currently,agonist of TRβ has been in clinical trials as a new lipid lowering agent,possibly via reverse cholesterol transport and trans-intestinal cholesterol excretion.The impacts of TR on lipid and energy metabolism are attracting increasingly intense attention.It is prospectively promising to fight clinically against hyperlipidaemia and obesity.It is most likely to grow to be a new target for lipid metabolism disorders and related diseases.