CAJ | 학술논문

瞬时受体电位(TRP)通道蛋白由一系列具有不同离子通透性和门控特性的亚家族组成,在哺乳动物的多种组织和细胞中广泛表达.近年来大量研究发现,TRP通道蛋白在胰岛β细胞中广泛表达,通过多种机制参与胰岛素分泌的调节,并在糖尿病并发症的发生、发展中发挥重要作用.对TRP家族的研究将有助于深入了解糖尿病及其并发症的病理过程,从而为糖尿病的治疗提供新的药物靶点.
순시수체전위(TRP)통도단백유일계렬구유불동리자통투성화문공특성적아가족조성,재포유동물적다충조직화세포중엄범표체.근년래대량연구발현,TRP통도단백재이도β세포중엄범표체,통과다충궤제삼여이도소분비적조절,병재당뇨병병발증적발생、발전중발휘중요작용.대TRP가족적연구장유조우심입료해당뇨병급기병발증적병리과정,종이위당뇨병적치료제공신적약물파점.
Transient receptor potential (TRP) proteins,which are widely expressed in various tissues and cells of mammals,constitute a family of cation channels with very diverse permeation and gating properties Recently,there is overwhelming evidence that TRP channels are abundantly expressed on islet β cells,and play significant roles both on the level of insulin release from the β cells and the occurrence and development of diabetic complications,with variety of mechanisms being involved in.Future analyses of TRP channels are likely to lead to better understanding of the complicated pathological processes of diabetes and its complications,thus offering new drug targets for treatment of diabetes.