国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2013年
5期
329-331
,共3页
脂肪肾素-血管紧张素-醛固酮系统%肥胖%血管紧张素Ⅱ%醛固酮
脂肪腎素-血管緊張素-醛固酮繫統%肥胖%血管緊張素Ⅱ%醛固酮
지방신소-혈관긴장소-철고동계통%비반%혈관긴장소Ⅱ%철고동
Adipose rennin-angiotensin-aldosterone system%Obesity%Angiotensin Ⅱ%Aldosterone
脂肪肾素-血管紧张素-醛固酮系统(RAAS)主要存在于白色脂肪组织,表达RAAS的所有成分,具有独立调节功能.游离脂肪酸增多可使脂肪RAAS过度激活,脂肪RAAS中活性成分血管紧张素Ⅱ及醛固酮可导致脂肪细胞异常分化、脂代谢异常、胰岛素敏感性下降、炎性反应加重,从而参与肥胖及其相关疾病的发生、发展.下调过度激活的脂肪RAAS可能是治疗肥胖及其相关代谢性和炎性反应性疾病的新靶点.
脂肪腎素-血管緊張素-醛固酮繫統(RAAS)主要存在于白色脂肪組織,錶達RAAS的所有成分,具有獨立調節功能.遊離脂肪痠增多可使脂肪RAAS過度激活,脂肪RAAS中活性成分血管緊張素Ⅱ及醛固酮可導緻脂肪細胞異常分化、脂代謝異常、胰島素敏感性下降、炎性反應加重,從而參與肥胖及其相關疾病的髮生、髮展.下調過度激活的脂肪RAAS可能是治療肥胖及其相關代謝性和炎性反應性疾病的新靶點.
지방신소-혈관긴장소-철고동계통(RAAS)주요존재우백색지방조직,표체RAAS적소유성분,구유독립조절공능.유리지방산증다가사지방RAAS과도격활,지방RAAS중활성성분혈관긴장소Ⅱ급철고동가도치지방세포이상분화、지대사이상、이도소민감성하강、염성반응가중,종이삼여비반급기상관질병적발생、발전.하조과도격활적지방RAAS가능시치료비반급기상관대사성화염성반응성질병적신파점.
Adipose rennin-angiotensin-aldosterone system (RAAS) mainly located in the white adipose tissue,it expresses all the ingredients of RAAS and takes autonomic regulation.The increase of free fatty acids may trigger the inappropriate activation of adipose RAAS.As the active ingredients of adipose RAAS,angiotensin Ⅱ and aldosterone result in the abnormal adipocyte differentiation,abnormal lipid metabolism,declining insulin sensitivity and increasing inflammation so as to play roles in the occurrence and development of obesity and its related diseases.Interference with inappropriate activation of adipose RAAS may be a new therapeutic target for obesity and its related metabolic and inflammatory disease.
