CAJ | 학술논문

目的研究城市社区居民高尿酸血症(HUA)的患病率及相关危险因素,提出有效防治措施.方法对6 273名18 ～ 75岁的桂林市象山区城市社区居民进行横断面调查,收集空腹静脉血样本及尿液检测血糖、肾功能、尿常规及尿微量白蛋白等,同时进行问卷调查和体格检查.结果在城市社区居民中HUA的总患病率为23.5％,男性为28.4％,显著高于女性的19.7％(x 2=1332.576,P＜0.01).校正血肌酐后,血尿酸水平与体重(或体重指数)、腰围、女性年龄等因素有关(r =0.150～0.269,P均＜0.01).男性受教育程度1～5年组及女性未受教育组血尿酸水平最高,分别为(411.4±91.2) μmol/L和(330.8±78.6) μmol/L.未受教育组HUA的患病率最高(33.6％),受教育程度6～10年组最低(22.4％,P ＜0.01).在男性以无工作组血尿酸水平最高,在女性以家务工作组血尿酸水平最高,分别为(418.9±107.6) μmol/L和(317.2 ±76.2) μmol/L.无工作组HUA患病率最高(41.0％),体力工作组最低(17.8％,P ＜0.01).饮酒和吸烟对尿酸水平也有显著影响,每天饮酒者和既往吸烟者尿酸水平最高,分别为(399.0±97.9)μmol/L和(408.3±94.6) μmol/L.慢性肾脏疾病(CKD)和高血压患者HUA患病率较高,分别为29.0％和32.0％,平均尿酸水平分别为(354.7±103.6) μmol/L和(356.1 ±93.9) μmol/L;而糖尿病患者与非糖尿病者HUA患病率无显著差异(x2=0.957,P＞0.05).结论广西城市社区居民HUA患病率较高,减轻体重、控制肥胖、避免吸烟、限制饮酒等生活方式的改变可能是有效的防治措施.
목적 연구성시사구거민고뇨산혈증(HUA)적환병솔급상관위험인소,제출유효방치조시.방법 대6 273명18 ～ 75세적계림시상산구성시사구거민진행횡단면조사,수집공복정맥혈양본급뇨액검측혈당、신공능、뇨상규급뇨미량백단백등,동시진행문권조사화체격검사.결과 재성시사구거민중HUA적총환병솔위23.5％,남성위28.4％,현저고우녀성적19.7％(x 2=1332.576,P＜0.01).교정혈기항후,혈뇨산수평여체중(혹체중지수)、요위、녀성년령등인소유관(r =0.150～0.269,P균＜0.01).남성수교육정도1～5년조급녀성미수교육조혈뇨산수평최고,분별위(411.4±91.2) μmol/L화(330.8±78.6) μmol/L.미수교육조HUA적환병솔최고(33.6％),수교육정도6～10년조최저(22.4％,P ＜0.01).재남성이무공작조혈뇨산수평최고,재녀성이가무공작조혈뇨산수평최고,분별위(418.9±107.6) μmol/L화(317.2 ±76.2) μmol/L.무공작조HUA환병솔최고(41.0％),체력공작조최저(17.8％,P ＜0.01).음주화흡연대뇨산수평야유현저영향,매천음주자화기왕흡연자뇨산수평최고,분별위(399.0±97.9)μmol/L화(408.3±94.6) μmol/L.만성신장질병(CKD)화고혈압환자HUA환병솔교고,분별위29.0％화32.0％,평균뇨산수평분별위(354.7±103.6) μmol/L화(356.1 ±93.9) μmol/L;이당뇨병환자여비당뇨병자HUA환병솔무현저차이(x2=0.957,P＞0.05).결론 엄서성시사구거민HUA환병솔교고,감경체중、공제비반、피면흡연、한제음주등생활방식적개변가능시유효적방치조시.
Objective To explore the incidence of hyperuricemia (HUA) in the urban community residents and the related risk factors,and to propose some effective prevention measures.Methods Totally 6 273 urban residents,aged 18-75 years,were screened with cross-sectional analysis in Xiangshan district of community Guilin.Fasting venous blood samples and urine were collected to evaluate blood glucose,renal function,urine routine,urinary albumin,etc.And questionnaire and physical examination were performed at the same time.Results The total incidence of HUA was 23.5％ in the urban community residents,and was 28.4％ in males,which was significantly higher than 19.7％ in females(x 2=1 332.576,P＜ 0.01).The serum uric acid levels were positive related to weight (or body mass index),waist circumference and female age when adjusting serum creatinine (r =0.150-0269,all P＜ 0.01).The serum uric acid levels in males received 1 to 5 years education and uneducated females were highest,which were (411.4 ± 91.2) μmol/L and (330.8 ± 78.6) μmol/L,respectively.The incidence of HUA in uneducated group was highest (33.6％),while lowest in 6 to 10 years education group (22.4％,P＜0.01).The serum uric acid levels in males without work and in females engaged in housework were highest,which were (418.9 ± 107.6) μmol/L and(317.2 ± 76.2) μmol/L,respectively.The incidence of HUA in residents without work was highest (41.0％),while lowest in residents engaged in physical work(17.8％,P＜0.01).Alcohol consumption and smoke influenced significantly on uric acid level,and highest uric acid levels were in the residents frequently drunk [(399.0 ± 97.9) μmol/L] and smoked in the past [(408.3±94.6) μmol/L].Patients with chronic kidney disease and hypertension had high incidences of HUA,which were 29.0％ and 32.0％,respectively.The mean serum uric acid levels were (354.7 ± 103.6)μmol/L and (356.1 ± 93.9)μmol/L in these patients.There was no significant difference of the incidences of HUA between patients with and without diabetes (x 2=0.957,P ＞0.05).Conclusion In the urban community residents of Guangxi,the incidence of HUA is high,and changing lifestyle such as losing weight,controlling obesity,avoiding smoke and restricting alcohol will be effective measures.