CAJ | 학술논문

流行病学研究显示,宫内发育迟缓(IUGR)是糖耐量异常、肥胖、2型糖尿病等代谢性疾病的危险因素.下丘脑神经肽Y表达上调、瘦素中枢受体分布异常、ghrelin作用异常及下丘脑-垂体-肾上腺轴功能紊乱;外周内分泌激素如瘦素、脂联素、胰岛素样生长因子-1的水平异常,胰岛素信号通路的改变以及代谢相关基因、酶的改变均为重要的影响因素.对糖、脂代谢异常机制的探讨可为防治IUGR个体出现代谢性疾病提供新的方向.
류행병학연구현시,궁내발육지완(IUGR)시당내량이상、비반、2형당뇨병등대사성질병적위험인소.하구뇌신경태Y표체상조、수소중추수체분포이상、ghrelin작용이상급하구뇌-수체-신상선축공능문란;외주내분비격소여수소、지련소、이도소양생장인자-1적수평이상,이도소신호통로적개변이급대사상관기인、매적개변균위중요적영향인소.대당、지대사이상궤제적탐토가위방치IUGR개체출현대사성질병제공신적방향.
Epidemiologic studies show intrauterine growth retardation (IUGR)is a risk factor of metabolic diseases including impaired glucose tolerance,obesity and type 2 diabetes.Up-regulation of hypothalamic neturopetide Y (NPY),changed distribution of leptin receptor,abnormal effect of ghrelin,dysfunction of hypothalamic-pituitary-adrenal axis,improperly level of peripheric hormones such as leptin,adiponectin and insulin-like growth factor-1,changed insulin signal pathway,abnormal levels of metabolism related genes and enzymes are important factors.Clarificating the mechanisms of disorder of glucolipid metabolism will supply a new direction for the prevention and treatment of metabolic diseases in individuals with IUGR.