CAJ | 학술논문

胰高糖素样肽-1(GLP-1)由中枢神经系统第四脑室边缘的孤束核尾部神经细胞分泌,后运输至下丘脑室旁核和背侧核.而其受体在中枢神经系统的分布主要集中在下丘脑,尤其是弓状核和室旁核、背内侧核、视上核.GLP-1通过与下丘脑相应核团上GLP-1受体结合,调节机体的多种生理功能,包括负向调节机体的摄食以及饮水行为、胃排空的速度,促进骨骼肌葡萄糖的摄取和糖原合成,降低血浆葡萄糖浓度,上调机体心率及降低血压等,从而起到调节机体的代谢水平及多重心血管保护的作用.
이고당소양태-1(GLP-1)유중추신경계통제사뇌실변연적고속핵미부신경세포분비,후운수지하구뇌실방핵화배측핵.이기수체재중추신경계통적분포주요집중재하구뇌,우기시궁상핵화실방핵、배내측핵、시상핵.GLP-1통과여하구뇌상응핵단상GLP-1수체결합,조절궤체적다충생리공능,포괄부향조절궤체적섭식이급음수행위、위배공적속도,촉진골격기포도당적섭취화당원합성,강저혈장포도당농도,상조궤체심솔급강저혈압등,종이기도조절궤체적대사수평급다중심혈관보호적작용.
Glucagon like peptide-1 (GLP-1) is secreted by nerve cells of the fourth ventricle solitary nucleus in central nervous system,which is transported to hypothalamus paraventricular nucleus and dorsal nucleus.Its receptors are mainly concentrated in hypothalamus,especially the arcuate nucleus and paraventricular nucleus,dorsal medial nucleus,supraoptic nucleus.GLP-1 could regulate a variety of physiological functions of the body through combining with GLP-1 receptors on the hypothalamic nuclei,including the negative regulation of feeding and drinking behavior of the body,the rate of gastric emptying,promoting skeletal muscle glucose uptake and glycogen synthesis,reducing plasma glucose concentration,increasing heart rate while lowering blood pressure,and so on.Thus it plays an important role in the protection of cardiovascular and regulation the metabolism of the body.