国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
2期
84-86
,共3页
Graves眼病%促甲状腺激素受体%信号转导
Graves眼病%促甲狀腺激素受體%信號轉導
Graves안병%촉갑상선격소수체%신호전도
Graves' ophthalmopathy%Thyroid stimulating hormone receptor%Signal transduction
近年来Graves眼病发病率逐年上升,引起人们的广泛关注.目前该病的发病机制尚不明确.促甲状腺激素受体(TSHR)信号转导通路是Graves眼病发病的关键因素.文章综述了TSHR信号转导通路在Graves眼病发病机制中作用的相关研究,介绍了TSHR信号转导通路具体途径,以及在此基础上开发的能结合TSHR并阻断信号转导通路的低相对分子质量TSHR拮抗剂NCGC00229600,为治疗Graves眼病开创了新前景.
近年來Graves眼病髮病率逐年上升,引起人們的廣汎關註.目前該病的髮病機製尚不明確.促甲狀腺激素受體(TSHR)信號轉導通路是Graves眼病髮病的關鍵因素.文章綜述瞭TSHR信號轉導通路在Graves眼病髮病機製中作用的相關研究,介紹瞭TSHR信號轉導通路具體途徑,以及在此基礎上開髮的能結閤TSHR併阻斷信號轉導通路的低相對分子質量TSHR拮抗劑NCGC00229600,為治療Graves眼病開創瞭新前景.
근년래Graves안병발병솔축년상승,인기인문적엄범관주.목전해병적발병궤제상불명학.촉갑상선격소수체(TSHR)신호전도통로시Graves안병발병적관건인소.문장종술료TSHR신호전도통로재Graves안병발병궤제중작용적상관연구,개소료TSHR신호전도통로구체도경,이급재차기출상개발적능결합TSHR병조단신호전도통로적저상대분자질량TSHR길항제NCGC00229600,위치료Graves안병개창료신전경.
In recent years,the incidence of Graves' ophthalmopathy(GO) has increased greatly,and caused widespread concem.Currently,the pathogenesis of GO is unclear.Studies have shown that receptor of thyroid stimulating hormone(TSHR) and its signaling pathway are key factors in GO.Here reviews the research progress of TSHR signal transduction pathway in the pathogenesis of GO.NCGC00229600,a small molecule TSHR antagonist may have great promise in the treatment or prevention of GO in the future.
