CAJ | 학술논문

糖尿病患者甲状腺癌的发病风险明显增加,主要的危险因素包括胰岛素抵抗、肥胖、高血糖及高血脂、促甲状腺激素水平升高、降糖药物如胰岛素和磺脲类药物以及维生素D缺乏等.上述因素通过如胰岛素样生长因子-1、cAMP/蛋白激酶A及氧化应激等信号通路促进甲状腺癌的发生、发展.
당뇨병환자갑상선암적발병풍험명현증가,주요적위험인소포괄이도소저항、비반、고혈당급고혈지、촉갑상선격소수평승고、강당약물여이도소화광뇨류약물이급유생소D결핍등.상술인소통과여이도소양생장인자-1、cAMP/단백격매A급양화응격등신호통로촉진갑상선암적발생、발전.
The incidence of thyroid cancer in patients with diabetes is significantly increased,which happens possibly through insulin resistance,obesity,high blood glucose and high triglyceride,elevated levels of thyroid stimulating hormone (TSH),antidiabetic therapy including insulin and sulfonylureas as well as vitamin D deficiency.All the above factors take part in the occurrence and development of thyroid cancer through different signal pathway such as insulin-like growth factor-1,cAMP/protein kinase A and oxidative stress.