CAJ | 학술논문

1型糖尿病(T1DM)的病理基础是胰岛β细胞的自身免疫性破坏,因此阻止该免疫进程对预防或治疗T1DM尤为重要.DiaPep277是一种由24个氨基酸组成的肽段,衍生于热休克蛋白60(HSP60)的C-末端区域.研究证明,它对糖尿病动物模型的自身免疫性T细胞具有免疫调节作用.临床研究表明,DiaPep277对初发T1DM患者的胰岛β细胞有保护作用,并具有安全性.
1형당뇨병(T1DM)적병리기출시이도β세포적자신면역성파배,인차조지해면역진정대예방혹치료T1DM우위중요.DiaPep277시일충유24개안기산조성적태단,연생우열휴극단백60(HSP60)적C-말단구역.연구증명,타대당뇨병동물모형적자신면역성T세포구유면역조절작용.림상연구표명,DiaPep277대초발T1DM환자적이도β세포유보호작용,병구유안전성.
Type 1 diabetes mellitus (T1DM) is characterized by the autoimmune destruction of islet β cells.Blocking the immune process is important for prevention and treatment of T1DM.DiaPep277 is composed of 24 amino acids derived from the C-terminal region of heat shock proteins 60 (HSP60) and manufactured as a synthetic peptide.DiaPep277 has an immune modulatory effect on T cells in animal models of diabetes.The results of the clinical trials indicate that DiaPep277 is safe and can preserve β cell function in patients with newly diagnosed T1DM.