CAJ | 학술논문

二甲双胍通过改善胰岛素抵抗(IR)、降低雄激素水平、调节脂代谢等作用,调节多囊卵巢综合征(PCOS)患者月经周期、促进排卵、减轻体重,从而增加妊娠率,在临床治疗中广泛应用.PCOS患者妊娠后由于IR加重,面临妊娠早期流产、妊娠糖尿病(GDM)、妊娠高血压及子痫前期等不良并发症,二甲双胍能减少PCOS患者妊娠早期流产、延缓GDM的发生,且对胎儿结局及出生后生长发育无明显影响.
이갑쌍고통과개선이도소저항(IR)、강저웅격소수평、조절지대사등작용,조절다낭란소종합정(PCOS)환자월경주기、촉진배란、감경체중,종이증가임신솔,재림상치료중엄범응용.PCOS환자임신후유우IR가중,면림임신조기유산、임신당뇨병(GDM)、임신고혈압급자간전기등불량병발증,이갑쌍고능감소PCOS환자임신조기유산、연완GDM적발생,차대태인결국급출생후생장발육무명현영향.
Metformin has a role in menstrual cycle adjustment,ovulation promotion and weight control of patients with polycystic ovary syndrome (PCOS) by improving insulin resistance (IR),lowering androgen level and regulating lipid metabolism,which can increase the rate of pregnancy and is widely applied in clinical treatment.Because of IR aggravation,patients with PCOS are often confronted with adverse complications,such as early pregnancy loss,gestational diabetes mellitus (GDM),pregnancy induced hypertension and pree-clampsia.Metformin can reduce early pregnancy loss and delay the occurrence of GDM in patients with PCOS,and shows no significant effects on fetal outcome,the postnatal growth and development of fetus.