CAJ | 학술논문

肥胖患者常出现甲状腺功能异常,这种异常在体重减轻后有所恢复,而甲状腺功能的异常又可引起脂肪堆积或体重增加.研究发现,人类脂肪细胞表达功能性的促甲状腺激素受体(TSHR),促甲状腺激素(TSH)可能作用于表达TSHR的脂肪细胞,调节脂肪细胞的生长、增殖、分化及脂肪因子的分泌.目前,TSH与体重指数、腰臀比、腰围等的关系尚存争议,但较多研究肯定了TSH与大部分肥胖相关参数存在正相关.
비반환자상출현갑상선공능이상,저충이상재체중감경후유소회복,이갑상선공능적이상우가인기지방퇴적혹체중증가.연구발현,인류지방세포표체공능성적촉갑상선격소수체(TSHR),촉갑상선격소(TSH)가능작용우표체TSHR적지방세포,조절지방세포적생장、증식、분화급지방인자적분비.목전,TSH여체중지수、요둔비、요위등적관계상존쟁의,단교다연구긍정료TSH여대부분비반상관삼수존재정상관.
Obese patients are often accompanied by thyroid dysfunction which would be recovered after weight loss.Besides,thyroid dysfunction may cause the accumulation of body fat or weight gain.Studies have found that human adipocytes express functional thyroid stimulating hormone(TSH)receptor (TSHR)and TSH may regulate the growth,proliferation,differentiation and the secretion of adipokines in adipocytes through TSHR.Although the association between TSH and obesity-related parameters such as body mass index,waist hip ratio,waist circumference is remain disputed,several investigations have demonstrated a positive correlation between TSH and most anthropometric measures.