国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2014年
4期
263-266
,共4页
GLP-1受体激动剂%炎症%氧化应激%信号通路
GLP-1受體激動劑%炎癥%氧化應激%信號通路
GLP-1수체격동제%염증%양화응격%신호통로
GLP-1 receptor agonist%Inflammation%Oxidative stress%Signal pathway
胰高血糖素样肽(GLP)-1受体激动剂的作用包括增强葡萄糖依赖性的胰岛素分泌、抑制葡萄糖依赖性的胰高血糖素的分泌、延缓胃排空、降低食欲、减少食物摄入量及减轻体重.此类药物还可通过减少炎性因子的释放、减少巨噬细胞浸润以及改善炎性反应相关的信号通路等机制降低机体C反应蛋白水平,改善机体炎性反应状态.另外,此类药物还通过降低活性氧簇、一氧化氮合酶和内皮素改善机体氧化应激状态.
胰高血糖素樣肽(GLP)-1受體激動劑的作用包括增彊葡萄糖依賴性的胰島素分泌、抑製葡萄糖依賴性的胰高血糖素的分泌、延緩胃排空、降低食欲、減少食物攝入量及減輕體重.此類藥物還可通過減少炎性因子的釋放、減少巨噬細胞浸潤以及改善炎性反應相關的信號通路等機製降低機體C反應蛋白水平,改善機體炎性反應狀態.另外,此類藥物還通過降低活性氧簇、一氧化氮閤酶和內皮素改善機體氧化應激狀態.
이고혈당소양태(GLP)-1수체격동제적작용포괄증강포도당의뢰성적이도소분비、억제포도당의뢰성적이고혈당소적분비、연완위배공、강저식욕、감소식물섭입량급감경체중.차류약물환가통과감소염성인자적석방、감소거서세포침윤이급개선염성반응상관적신호통로등궤제강저궤체C반응단백수평,개선궤체염성반응상태.령외,차류약물환통과강저활성양족、일양화담합매화내피소개선궤체양화응격상태.
The roles of glucagon-like peptide-1 (GLP-1) receptor agonist includes enhancing glucose dependent insulin secretion,inhibiting glucose dependent glucagon secretion,delaying gastric emptying,reducing appetite,food intake and body weight.These drugs can reduce the level of C reactive protein and improve inflammation by reducing the release of inflammatory factors,reducing macrophage infiltration and improving inflammation related signaling pathway.In addition,GLP-1 also improves oxidative stress by reducing reactive oxygen species,nitric oxide synthase and endothelin-1.
