CAJ | 학술논문

miR-375是一类特异性高表达于胰腺组织的非编码小RNA.研究表明,miR-375直接调控多种胰岛组织中特异性转录因子的表达,参与调控多种基因及信号转导通路,影响糖、脂代谢,在2型糖尿病的发生、发展中起一定作用.miR-375对胰岛β细胞分化、胰岛素分泌及糖、脂代谢的调控作用可能为2型糖尿病的早期干预和治疗提供新方向.
miR-375시일류특이성고표체우이선조직적비편마소RNA.연구표명,miR-375직접조공다충이도조직중특이성전록인자적표체,삼여조공다충기인급신호전도통로,영향당、지대사,재2형당뇨병적발생、발전중기일정작용.miR-375대이도β세포분화、이도소분비급당、지대사적조공작용가능위2형당뇨병적조기간예화치료제공신방향.
miR-375 is a small non-coding RNA,which is highly expressed in islet tissue.Studies show that miR-375 could directly regulate the expression of a variety of specific transcription factor in pancreas and differentiation of islet beta cells,affect insulin secretion,modulate glucose and lipid metabolism,and involve in differentiation of adipocytes by regulating many genes and signal pathways,so it might play an important role in the mechanism of type 2 diabetes.In summary,the regulation of miR-375 on type 2 diabetes may provide a new direction for the early prevention and treatment of type 2 diabetes.