CAJ | 학술논문

炎性反应在糖尿病肾病(DN)的发生、发展中起重要作用.高糖作为始动因素,与晚期糖基化终末产物(AGEs)、氧化应激及肾内血流动力学的改变共同引起了糖尿病肾脏炎性反应的发生.而二甲双胍作为治疗糖尿病的一线药物,近年研究显示其除降糖作用以外,还可通过激活腺苷酸活化蛋白激酶(AMPK)、抗氧化应激和改善胰岛素抵抗等机制发挥抗炎作用,从而预防和延缓DN的发生和发展.
염성반응재당뇨병신병(DN)적발생、발전중기중요작용.고당작위시동인소,여만기당기화종말산물(AGEs)、양화응격급신내혈류동역학적개변공동인기료당뇨병신장염성반응적발생.이이갑쌍고작위치료당뇨병적일선약물,근년연구현시기제강당작용이외,환가통과격활선감산활화단백격매(AMPK)、항양화응격화개선이도소저항등궤제발휘항염작용,종이예방화연완DN적발생화발전.
Inflammation plays an important role in the occurrence and development of diabetic nephropathy (DN).Hyperglycemia as the initiating factor,combined with advanced glycosylation end products (AGEs),oxidative stress and the renal hemodynamic changes causes a inflammation in diabetic renal tissue.Except the hypoglycemic effect,metformin,as the first-line drugs for the treatment of diabetes,can prevent and delay the occurrence and progress of DN through some anti-inflammatory mechanisms,which include activation of the AMP activated protein kinase (AMPK),anti-oxidative stress and improvement of insulin resistance.