CAJ | 학술논문

组蛋白修饰是表观遗传学的重要组成部分,其在甲状腺癌的诊断、治疗等方面的研究越来越多.甲基化、乙酰化、磷酸化及泛素化组蛋白修饰均可参与甲状腺癌的发生.组蛋白修饰可参与调控甲状腺癌细胞的分化,影响肿瘤细胞的增殖.组蛋白去乙酰化酶抑制剂可用于甲状腺癌的治疗.
조단백수식시표관유전학적중요조성부분,기재갑상선암적진단、치료등방면적연구월래월다.갑기화、을선화、린산화급범소화조단백수식균가삼여갑상선암적발생.조단백수식가삼여조공갑상선암세포적분화,영향종류세포적증식.조단백거을선화매억제제가용우갑상선암적치료.
Histone modification is one of the major forms of epigenetic modifications,there are more and more researches on the applications of histone modifications in the diagnosis and treatment of thyroid tumor.Methylation,acetylation,phosphorylation and ubiquitin of histone modification involve in thyroid cancer.Histone modification can regulate the differentiation of thyroid cancer,influence the proliferation of tumor cells.Histone deacetylases may be used in the treatment of thyroid tumors.