CAJ | 학술논문

维生素D是一种脂溶性类固醇激素,其除从传统意义上调节钙、磷平衡及骨代谢外,还具有广泛的骨外生物学作用,如参与机体能量代谢和糖、脂代谢.维生素D缺乏可能引起代谢综合征,而非酒精性脂肪性肝病(NAFLD)是代谢综合征在肝脏中的表现形式.有证据显示,维生素D可通过介导胆汁酸代谢、减轻胰岛素抵抗以及改善肝纤维化这3条途径发挥对NAFLD的保护作用.
유생소D시일충지용성류고순격소,기제종전통의의상조절개、린평형급골대사외,환구유엄범적골외생물학작용,여삼여궤체능량대사화당、지대사.유생소D결핍가능인기대사종합정,이비주정성지방성간병(NAFLD)시대사종합정재간장중적표현형식.유증거현시,유생소D가통과개도담즙산대사、감경이도소저항이급개선간섬유화저3조도경발휘대NAFLD적보호작용.
Vitamin D is a kind of fat-soluble steroid hormones known for its roles in the modulating of calcium absorption and bone metabolism.It is also associated with energy metabolism and glucolipid metabolism.Vitamin D has sparked widespread interest because of its involvement in metabolic syndrome.Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of metabolic syndrome.Evidences show that vitamin D may play protective roles on NAFLD through the improvement of bile acid metabolism,insulin resistance and liver fibrosis.