CAJ | 학술논문

目的观察糖尿病下肢动脉闭塞症(DAO)患者血管内皮细胞功能的变化及脉管复康片干预的作用机制.方法 66例DAO患者按随机表法分为治疗组与对照组,每组33例,分别服用脉管复康片4片/次,3次/d;或通塞脉片4片/次,3次/d,疗程均为8周.观察两组患者治疗后临床症状、体征、光电血流描记、踝/肱比指数以及血液流变学、内皮细胞因子等指标.结果治疗组在改善临床症状方面优于对照组(P＜0.05);治疗后两组血黏度、纤维蛋白原均有降低,治疗组比对照组更为显著(P＜0.01);治疗后在血浆一氧化氮、内皮素-1水平变化方面,治疗组效果优于对照组,有显著性差异(P＜0.01).结论脉管复康片可改善DAO患者临床症状,主要是通过调节血管内皮细胞功能,降低血黏度发挥作用.
목적 관찰당뇨병하지동맥폐새증(DAO)환자혈관내피세포공능적변화급맥관복강편간예적작용궤제.방법 66례DAO환자안수궤표법분위치료조여대조조,매조33례,분별복용맥관복강편4편/차,3차/d;혹통새맥편4편/차,3차/d,료정균위8주.관찰량조환자치료후림상증상、체정、광전혈류묘기、과/굉비지수이급혈액류변학、내피세포인자등지표.결과 치료조재개선림상증상방면우우대조조(P＜0.05);치료후량조혈점도、섬유단백원균유강저,치료조비대조조경위현저(P＜0.01);치료후재혈장일양화담、내피소-1수평변화방면,치료조효과우우대조조,유현저성차이(P＜0.01).결론 맥관복강편가개선DAO환자림상증상,주요시통과조절혈관내피세포공능,강저혈점도발휘작용.
Objective To investigate the effects and mechanisms of Maiguan Fukang tablets on the function of vascular endothelial cells in patients with diabetic arterial occlusion of lower extremities (DAO).Methods Sixty-six patients with DAO were divided into treatment group and control group by random table method,with 33 patients in each group.Four pieces of Maiguan Fukang tablets or Tongsaimai tablets three times a day were prescribed to the patients for 8 weeks.The clinical symptoms and signs,photoelectric flow tracings,ankle brachial index,heamorheology,markers of endothelial cell function were assessed after treatment.Results Clinical symptoms were improved in treatment group compared with control group (P ＜ 0.05).Blood viscosity and fibrinogen level were reduced in both groups,but were more evident in treatment group (P ＜ 0.01).Plasma nitric oxide and endothelin-1 level in treatment group were also improved significantly compared with those in control group (P ＜ 0.01).Conclusion Maiguan Fukang tablets can improve the clinical symptoms for patients with DAO,which may act through regulating vascular endothelial function and decreasing blood viscosity.