国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2013年
1期
19-22
,共4页
朱海献%张敏%钟富强%赵雷%郜宪林
硃海獻%張敏%鐘富彊%趙雷%郜憲林
주해헌%장민%종부강%조뢰%고헌림
脑出血%卒中%脑缺血%蛋白尿%危险因素%生物学标记
腦齣血%卒中%腦缺血%蛋白尿%危險因素%生物學標記
뇌출혈%졸중%뇌결혈%단백뇨%위험인소%생물학표기
Cerebral Hemorrhage%Stroke%Brain Ischemia%Albuminuria%Risk Factors%Biological Markers
目的 探讨小动脉闭塞性卒中(small artery occlusion,SAO)患者脑微出血(cerebralmicrobleed,CMB)的危险因素及其与24 h微量白蛋白尿(microalbuminuria,mALB)的相关性.方法 纳入SAO患者,采用磁敏感加权成像检测CMB,并对患者的人口统计学和临床特征以及24 h mALB进行比较.采用多变量logistic回归分析确定SAO患者CMB的独立危险因素.采用Spearman相关分析探讨24 h mALB与CMB程度的相关性.结果 共纳入90例SAO患者,其中35例(38.89％)存在CMB,主要分布于基底节/丘脑及幕下(62％).CMB组患者年龄[(70.8±5.4)岁对(67.3±8.1)岁;=2.461,P=0.016]、高血压构成比(80.0％对52.7％;x2=6.851,P=0.009)以及24 h mALB水平[(16.257±6.031)mg/24 h对(11.910±5.458)mg/24 h;t3.536,P=0.001]均显著高于无CMB组.Spearman等级相关分析显示,24 h mALB与SAO患者CMB严重程度呈现显著正相关(rs =0.795,P =0.000),24 h mALB水平越高,CMB程度越重.多变量logistic回归分析显示,仅24 h mALB是SAO患者存在CMB的独立危险因素(优势比1.100,95％可信区间1.031 ～1.176;P=0.002).结论 24 hmALB是SAO患者存在CMB的独立危险因素,24 h mALB水平与CMB严重程度呈正相关,可作为小血管损伤的一个标志.
目的 探討小動脈閉塞性卒中(small artery occlusion,SAO)患者腦微齣血(cerebralmicrobleed,CMB)的危險因素及其與24 h微量白蛋白尿(microalbuminuria,mALB)的相關性.方法 納入SAO患者,採用磁敏感加權成像檢測CMB,併對患者的人口統計學和臨床特徵以及24 h mALB進行比較.採用多變量logistic迴歸分析確定SAO患者CMB的獨立危險因素.採用Spearman相關分析探討24 h mALB與CMB程度的相關性.結果 共納入90例SAO患者,其中35例(38.89％)存在CMB,主要分佈于基底節/丘腦及幕下(62％).CMB組患者年齡[(70.8±5.4)歲對(67.3±8.1)歲;=2.461,P=0.016]、高血壓構成比(80.0％對52.7％;x2=6.851,P=0.009)以及24 h mALB水平[(16.257±6.031)mg/24 h對(11.910±5.458)mg/24 h;t3.536,P=0.001]均顯著高于無CMB組.Spearman等級相關分析顯示,24 h mALB與SAO患者CMB嚴重程度呈現顯著正相關(rs =0.795,P =0.000),24 h mALB水平越高,CMB程度越重.多變量logistic迴歸分析顯示,僅24 h mALB是SAO患者存在CMB的獨立危險因素(優勢比1.100,95％可信區間1.031 ～1.176;P=0.002).結論 24 hmALB是SAO患者存在CMB的獨立危險因素,24 h mALB水平與CMB嚴重程度呈正相關,可作為小血管損傷的一箇標誌.
목적 탐토소동맥폐새성졸중(small artery occlusion,SAO)환자뇌미출혈(cerebralmicrobleed,CMB)적위험인소급기여24 h미량백단백뇨(microalbuminuria,mALB)적상관성.방법 납입SAO환자,채용자민감가권성상검측CMB,병대환자적인구통계학화림상특정이급24 h mALB진행비교.채용다변량logistic회귀분석학정SAO환자CMB적독립위험인소.채용Spearman상관분석탐토24 h mALB여CMB정도적상관성.결과 공납입90례SAO환자,기중35례(38.89％)존재CMB,주요분포우기저절/구뇌급막하(62％).CMB조환자년령[(70.8±5.4)세대(67.3±8.1)세;=2.461,P=0.016]、고혈압구성비(80.0％대52.7％;x2=6.851,P=0.009)이급24 h mALB수평[(16.257±6.031)mg/24 h대(11.910±5.458)mg/24 h;t3.536,P=0.001]균현저고우무CMB조.Spearman등급상관분석현시,24 h mALB여SAO환자CMB엄중정도정현현저정상관(rs =0.795,P =0.000),24 h mALB수평월고,CMB정도월중.다변량logistic회귀분석현시,부24 h mALB시SAO환자존재CMB적독립위험인소(우세비1.100,95％가신구간1.031 ～1.176;P=0.002).결론 24 hmALB시SAO환자존재CMB적독립위험인소,24 h mALB수평여CMB엄중정도정정상관,가작위소혈관손상적일개표지.
Objective To investigate the risk factors for cerebral microbleeds (CMBs) and its correlation with the 24 h microalbuminuria (mALB) in patients with small artery occlusion (SAO).Methods The patients with SAO were enrolled.CMBs were detected with susceptibility-weighted imaging.The demographic and clinical characteristics and 24 h mALB of the patients were compared.Multivariate logistic regression analysis was used to identify the independent risk factors for CMB in patients with SAO.Spearman correlation analysis was used to investigate the correlation between the 24 h mALB and the degree of CMBs.Results A total of 90 patients with SAO were enrolled and 35 patients (38.89％) had CMBs.CMBs mainly distributed in basal ganglia/thalamus and infratentorial (62％) regions.The Age (70.8 ± 5.4 vs.67.3 ± 8.1; t =2.461,P =0.016),proportion of hypertension (80.0％ vs.52.7％ ;x2 =6.851,P =0.009),and 24 h mALB levels (16.257 ± 6.031 mg/24 h vs.11.910 ±5.458 mg/24 h; t =3.536,P =0.001) in the CBM group were significantly higher than those in the non-CMB group.Spearman rank correlation analysis showed that the 24 h mALB and the severity of CMB in patients with SAO showed a significant positive correlation (rs =0.795,P =0.000).The higher the 24 h mALB level was,the more severe the CMB degree would be.Multivariate logistic regression analysis showed that only 24 h mALB was the only independent risk factor for CMBs in patients with SAO (odds ratio,1.100,95％ confidence interval 1.031-1.176; P =0.002).Conclusions The 24 h mALB is an independent risk factor for CMB in patients with SAO.The 24 h mALB level is positively correlated with the severity of CMB,and it may be used as a marker for small vascular injury.
