国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2013年
1期
59-64
,共6页
动脉粥样硬化%氧化性应激%内皮,血管%线粒体%活性氧类%抗氧化药
動脈粥樣硬化%氧化性應激%內皮,血管%線粒體%活性氧類%抗氧化藥
동맥죽양경화%양화성응격%내피,혈관%선립체%활성양류%항양화약
Atherosclerosis%Oxidative Stress%Endothelium,Vascular%Mitochondria%Reactive Oxygen Species%Antioxidants
在病理条件下,机体内促氧化应激酶激活、线粒体呼吸链异常、氧自由基清除能力下降,导致氧自由基和促氧化因子生成增多.上述有害物质累积引起动脉管壁和血液成分发生相应的改变,如内皮依赖性舒张功能减退、炎性细胞因子激活、内皮结构破坏、血管平滑肌细胞增殖以及泡沫细胞形成等,从而在动脉粥样硬化的发生和发展过程中发挥着关键作用.目前,针对抗氧化治疗在心脑血管事件预防中的作用存在争议,有待进一步研究.
在病理條件下,機體內促氧化應激酶激活、線粒體呼吸鏈異常、氧自由基清除能力下降,導緻氧自由基和促氧化因子生成增多.上述有害物質纍積引起動脈管壁和血液成分髮生相應的改變,如內皮依賴性舒張功能減退、炎性細胞因子激活、內皮結構破壞、血管平滑肌細胞增殖以及泡沫細胞形成等,從而在動脈粥樣硬化的髮生和髮展過程中髮揮著關鍵作用.目前,針對抗氧化治療在心腦血管事件預防中的作用存在爭議,有待進一步研究.
재병리조건하,궤체내촉양화응격매격활、선립체호흡련이상、양자유기청제능력하강,도치양자유기화촉양화인자생성증다.상술유해물질루적인기동맥관벽화혈액성분발생상응적개변,여내피의뢰성서장공능감퇴、염성세포인자격활、내피결구파배、혈관평활기세포증식이급포말세포형성등,종이재동맥죽양경화적발생화발전과정중발휘착관건작용.목전,침대항양화치료재심뇌혈관사건예방중적작용존재쟁의,유대진일보연구.
Under pathological conditions,promoting oxidative stress kinase to be activated in the body,mitochondrial respiratory chain abnormalities,and decreased oxygen free radical scavenging capacity lead to increased oxygen free radicals and pro-oxidant factors.The accunulation of the above harmful substances lead to the corresponding changes of arterial wall and blood components,such as endothelium-dependent relaxation dysfunction,inflammatory cytokine activation,endothelial structural damage,vascular smooth muscle cell proliferation,and foam cell formation,thus play key roles in the processes of the occurrence and development of atherosclerosis.The role of antioxidant therapy in the prevention of cardio-cerebrovascular events remains controversial and needs to be further studied.
