CAJ | 학술논문

腺苷酸活化蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)是一种丝氨酸/苏氨酸蛋白激酶,为机体细胞内能量调节的开关.在营养缺乏、缺血等情况下,AMPK系统激活,作为代谢和应激信号转导元件调节下游靶蛋白表达.急性脑缺血后,AMPK被激活并加重神经元凋亡,而给予AMPK抑制剂则可减轻脑缺血损伤.卒中后,AMPK激活可导致脑源性神经生长因子表达上调和内皮型一氧化氮合酶活化,对神经元再生和修复起着保护作用.文章对AMPK在实验性脑缺血中作用的研究进展进行了综述.
선감산활화단백격매(adenosine monophosphate-activated protein kinase,AMPK)시일충사안산/소안산단백격매,위궤체세포내능량조절적개관.재영양결핍、결혈등정황하,AMPK계통격활,작위대사화응격신호전도원건조절하유파단백표체.급성뇌결혈후,AMPK피격활병가중신경원조망,이급여AMPK억제제칙가감경뇌결혈손상.졸중후,AMPK격활가도치뇌원성신경생장인자표체상조화내피형일양화담합매활화,대신경원재생화수복기착보호작용.문장대AMPK재실험성뇌결혈중작용적연구진전진행료종술.
Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine protein kinase,which is a energy regulation switch in the cells of the body.In the case of nutritional deficiencies and ischemia,AMPK system is activated as the metabolism and stress signal transduction component to regulate the expression of downstream target proteins.After acute ischemic stroke,AMPK is activated and aggravates neuronal apoptosis,and giving AMPK inhibitor may reduce cerebral ischemic injury.The activation of AMPK after stroke may result in the upregulation of brain-derived neurotrophic factor expression and the activation of endothelial nitric oxide synthase,and they play the protective roles for neuronal regeneration and repair.This article reviews the advances in research on the roles of AMPK in experimental cerebral ischemia.