CAJ | 학술논문

神经珠蛋白(neuroglobin,Ngb)是一种特异性表达于脑组织的携氧球蛋白,参与能量代谢、线粒体功能以及细胞存活和增殖的信号通路调节.在生理条件下,Ngb以亚铁脱氧六配体形式存在,具有较强的氧亲和能力.缺血缺氧时,脑组织内的Ngb表达上调,并通过与其下游的多种蛋白相互作用,对损伤脑组织起着保护作用.
신경주단백(neuroglobin,Ngb)시일충특이성표체우뇌조직적휴양구단백,삼여능량대사、선립체공능이급세포존활화증식적신호통로조절.재생리조건하,Ngb이아철탈양륙배체형식존재,구유교강적양친화능력.결혈결양시,뇌조직내적Ngb표체상조,병통과여기하유적다충단백상호작용,대손상뇌조직기착보호작용.
Neuroglobin (Ngb) is an oxygen-carrying globin that specifically expresses in brain tissue.It is involved in energy metabolism,mitochondrial function,as well as cell survival and proliferation of signaling pathway regulation.Under physiological conditions,Ngb presents as a form of ferrous deoxy hexacoordination,which has stronger oxygen affinity.During ischemia and hypoxia,the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream,and plays a protective role for the damaged brain tissue.