国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2014年
1期
67-71
,共5页
脂氧素A4%脑缺血%再灌注损伤%炎症
脂氧素A4%腦缺血%再灌註損傷%炎癥
지양소A4%뇌결혈%재관주손상%염증
Lipoxin A4%Brain Ischemia%Reperfusion Injury%Inflammation
脂氧素A4是一种花生四烯酸代谢产物,是机体内重要的内源性抗炎介质,被称为炎症的“刹车信号”.炎症反应是造成脑缺血再灌注损伤的重要因素.脂氧素A4能通过抑制炎症反应发挥神经保护作用.此外,脂氧素A4还能降低血脑屏障通透性、减轻脑水肿和促进神经功能恢复.文章对脂氧素A4在脑缺血再灌注中的保护作用及其机制进行了综述.
脂氧素A4是一種花生四烯痠代謝產物,是機體內重要的內源性抗炎介質,被稱為炎癥的“剎車信號”.炎癥反應是造成腦缺血再灌註損傷的重要因素.脂氧素A4能通過抑製炎癥反應髮揮神經保護作用.此外,脂氧素A4還能降低血腦屏障通透性、減輕腦水腫和促進神經功能恢複.文章對脂氧素A4在腦缺血再灌註中的保護作用及其機製進行瞭綜述.
지양소A4시일충화생사희산대사산물,시궤체내중요적내원성항염개질,피칭위염증적“찰차신호”.염증반응시조성뇌결혈재관주손상적중요인소.지양소A4능통과억제염증반응발휘신경보호작용.차외,지양소A4환능강저혈뇌병장통투성、감경뇌수종화촉진신경공능회복.문장대지양소A4재뇌결혈재관주중적보호작용급기궤제진행료종술.
Lipoxin A4 is an arachidonic acid metabolite,it is an important endogenous anti-inflammatory mediators in the body,which is known as an inflammatory "braking signal." Inflammatory response is an important factor for causing cerebral ischemia-reperfusion injury.Lipoxin A4 can exert neuroprotective effects by inhibiting inflammatory response.In addition,lipoxin A4 can also reduce blood-brain barrier permeability,reduce cerebral edema,and promote recovery of neurological function.This article reviews the neuroprotective roles and mechanisms of lipoxin A4 in cerebral ischemia-reperfusion.
