国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2014年
4期
274-278
,共5页
叶芳%羊洁%张欣%郭富强
葉芳%羊潔%張訢%郭富彊
협방%양길%장흔%곽부강
卒中%脑缺血%高半胱氨酸%动脉粥样硬化%超声检查%磁共振成像%危险因素
卒中%腦缺血%高半胱氨痠%動脈粥樣硬化%超聲檢查%磁共振成像%危險因素
졸중%뇌결혈%고반광안산%동맥죽양경화%초성검사%자공진성상%위험인소
Stroke%Brain Ischemia%Homocysteine%Atherosclerosis%Ultrasonography%Magnetic Resonance Imaging%Risk Factors
目的 探讨血高半胱氨酸(homocysteine,Hcy)与大动脉粥样硬化性卒中(large artery atherosclerosis,LAA)的关系.方法 连续纳入LAA和小动脉闭塞性卒中(small artery occlusion,SAO)患者,比较人口统计学、基线临床资料以及实验室化验结果.应用多变量logistic回归分析确定LAA的独立危险因素.采用Spearman相关分析血清Hcy浓度与颈动脉斑块积分之间的相关性.结果 共纳入117例LAA和SAO患者,LAA组42例,SAO组75例.LAA组血浆Hcy水平[中位数(四分位间距)][15.35(12.20～20.43) μmol/L对12.40(10.40～15.00) μmol/L;Z=-2.540,P=0.011]和颈动脉斑块积分[(6.30 ±4.11)mm对(4.19 ±2.84)mm;t=2.952,P=o.o04]以及处于血浆Hcy水平三分位数分组患者比例(x2=10.697,P=0.005)均显著性高于SAO组.多变量logistic回归分析显示,血浆Hcy浓度处于第3三分位数(＞ 15.3 μmol/L)是LAA的独立危险因素(优势比4.739,95％可信区间1.696～13.241;P=0.003).而且,血清Hcy浓度与颈动脉斑块积分呈显著正相关联系(r =0.245,P=0.008).结论 血浆Hcy水平与颈动脉粥样硬化严重程度呈正相关,血浆Hcy＞15.3mol/L是LAA的独立危险因素.
目的 探討血高半胱氨痠(homocysteine,Hcy)與大動脈粥樣硬化性卒中(large artery atherosclerosis,LAA)的關繫.方法 連續納入LAA和小動脈閉塞性卒中(small artery occlusion,SAO)患者,比較人口統計學、基線臨床資料以及實驗室化驗結果.應用多變量logistic迴歸分析確定LAA的獨立危險因素.採用Spearman相關分析血清Hcy濃度與頸動脈斑塊積分之間的相關性.結果 共納入117例LAA和SAO患者,LAA組42例,SAO組75例.LAA組血漿Hcy水平[中位數(四分位間距)][15.35(12.20～20.43) μmol/L對12.40(10.40～15.00) μmol/L;Z=-2.540,P=0.011]和頸動脈斑塊積分[(6.30 ±4.11)mm對(4.19 ±2.84)mm;t=2.952,P=o.o04]以及處于血漿Hcy水平三分位數分組患者比例(x2=10.697,P=0.005)均顯著性高于SAO組.多變量logistic迴歸分析顯示,血漿Hcy濃度處于第3三分位數(＞ 15.3 μmol/L)是LAA的獨立危險因素(優勢比4.739,95％可信區間1.696～13.241;P=0.003).而且,血清Hcy濃度與頸動脈斑塊積分呈顯著正相關聯繫(r =0.245,P=0.008).結論 血漿Hcy水平與頸動脈粥樣硬化嚴重程度呈正相關,血漿Hcy＞15.3mol/L是LAA的獨立危險因素.
목적 탐토혈고반광안산(homocysteine,Hcy)여대동맥죽양경화성졸중(large artery atherosclerosis,LAA)적관계.방법 련속납입LAA화소동맥폐새성졸중(small artery occlusion,SAO)환자,비교인구통계학、기선림상자료이급실험실화험결과.응용다변량logistic회귀분석학정LAA적독립위험인소.채용Spearman상관분석혈청Hcy농도여경동맥반괴적분지간적상관성.결과 공납입117례LAA화SAO환자,LAA조42례,SAO조75례.LAA조혈장Hcy수평[중위수(사분위간거)][15.35(12.20～20.43) μmol/L대12.40(10.40～15.00) μmol/L;Z=-2.540,P=0.011]화경동맥반괴적분[(6.30 ±4.11)mm대(4.19 ±2.84)mm;t=2.952,P=o.o04]이급처우혈장Hcy수평삼분위수분조환자비례(x2=10.697,P=0.005)균현저성고우SAO조.다변량logistic회귀분석현시,혈장Hcy농도처우제3삼분위수(＞ 15.3 μmol/L)시LAA적독립위험인소(우세비4.739,95％가신구간1.696～13.241;P=0.003).이차,혈청Hcy농도여경동맥반괴적분정현저정상관련계(r =0.245,P=0.008).결론 혈장Hcy수평여경동맥죽양경화엄중정도정정상관,혈장Hcy＞15.3mol/L시LAA적독립위험인소.
Objective To investigate the relationship between serum homocysteine (Hcy) and large artery atherosclerosis (LAA).Medods The consecutive stroke patients with LAA and small artery occlusion (SAO) were enrolled.The demographics,baseline clinical data,and laboratory test results were compared.Multivariate logistic regression analysis was used to identify the independent risk factors for LAA.Spearman correlation analysis was used to analyze the correlation between serum Hcy concentration and carotid plaque scores.Results A total of 117 patients with LAA and SAO were enrolled,42 were in the LAA group and 75 were in the SAO group.The plasma Hcy levels (median [interquartile range] 15.35 [12.20-20.43] μmol/Lvs.12.40 [10.40-15.00] μmoFL; Z=-2.540,P=0.011),the carotid plaque scores (6.30 ±4.11 mm vs.4.19 ±2.84 mm; t =2.952,P=0.004),and the proportion of plasma Hcy level at tertile groups of the patients (x2 =10.697,P =0.005) of the LAA plasma group were all significantly higher than those of the SAO group.Multivariate logistic regression analysis showed that the plasma Hcy concentration was in the third tertile (＞ 15.3 μmol/L),and it was an independent risk factor for LAA (odds ratio 4.739,95％ confidence interval 1.696-13.241; P =0.003).Moreover,there was a significant positive correlation between the serum Hcy concentration and the carotid plaque scores (r =0.245,P =0.008).Conclusions The plasma Hcy levels were positively correlated with the severity of carotid atherosclerosis.The Hcy ＞ 15.3 μmol/L was an independent risk factor for LAA.
