CAJ | 학술논문

恶性黑素瘤是一种皮肤起源的恶性肿瘤,其发生率和致死率在世界范围逐年上升.表观遗传学是一种涉及基因功能但不涉及DNA序列改变的遗传机制,DNA甲基化是其中最重要的机制之一,其作为连接表型与基因型重要纽带,是恶性黑素瘤发生发展中具有特异性和标志性的遗传学事件.通过逆转这些异常的甲基化状态实现更有针对性的治疗是新的研究方向.
악성흑소류시일충피부기원적악성종류,기발생솔화치사솔재세계범위축년상승.표관유전학시일충섭급기인공능단불섭급DNA서렬개변적유전궤제,DNA갑기화시기중최중요적궤제지일,기작위련접표형여기인형중요뉴대,시악성흑소류발생발전중구유특이성화표지성적유전학사건.통과역전저사이상적갑기화상태실현경유침대성적치료시신적연구방향.
Malignant melanoma is a highly aggressive neoplasia of melanocytic origin with constantly growing incidence and mortality rates worldwide.Epigenetics is a heritable alteration of gene function without an alteration in DNA sequence.As one of the most cardinal forms of epigenetic modification,DNA methylation is not only an important tie between genotype and phenotype,but also a specific and well characterized genetic event in the development of malignant melanoma.To reverse abnormal methylation status may offer a new approach to targeted therapy of malignant melanoma.