国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2014年
9期
650-655
,共6页
颅内动脉硬化%脑白质疏松%脑缺血%磁共振波谱学%事件相关电位,P300
顱內動脈硬化%腦白質疏鬆%腦缺血%磁共振波譜學%事件相關電位,P300
로내동맥경화%뇌백질소송%뇌결혈%자공진파보학%사건상관전위,P300
Intracranial Arteriosclerosis%Leukoaraiosis%Brain Ischemia%Magnetic Resonance Spectroscopy%Event-Related Potentials,P300
目的 探讨质子磁共振波谱(proton magnetic resonance spectroscopy,1H-MRS)在脑白质病变(white matter lesion,WML)患者中的应用.方法 纳入WML患者,结合影像学表现和临床症状分为皮质下动脉硬化性脑病(subcortical arteriosclerotic encephalopathy,SAE)组和单纯脑白质疏松(leukoaraiosis,LA)组.所有病例均完成MRI、1 H-MRS和听觉事件相关电位P300检查.1 H-MRS多体素采集范围为侧脑室周围白质区,记录N-乙酰天冬氨酸(N-acetylaspartate,NAA)、肌酐(creatine,Cr)、胆碱(choline,Cho)、NAA/Cr以及P300潜伏期和波幅.结果 共纳入WML患者50例,其中SAE30例,单纯LA 20例.SAE组NAA(中位数,四分位数间距;M,IQR)[0.732 (0.680 ～0.804)对0.915(0.866 ～ 0.963);Z=-5.634,P＜ 0.001]和NAA/Cr(M,IQR)[1.533(1.317～ 1.817)对2.003(1.794～2.387);Z=-3.921,P＜0.001]均较单纯LA组显著性降低.SAE组P300潜伏期(M,IQR)较单纯LA组显著延长[370.50(363.50 ～ 385.25)ms对351.50(342.75 ～ 359.00)ms;Z=-4.382,P＜ 0.001],且波幅(M,IQR)较单纯LA组显著性降低[4.35(2.90 ～7.20)mV对6.95(5.93 ～9.10)mV;Z=-2.942,P=0.003].结论 1 H-MRS可用于鉴别SAE与单纯LA患者,为预防LA进展为SAE提供客观依据.
目的 探討質子磁共振波譜(proton magnetic resonance spectroscopy,1H-MRS)在腦白質病變(white matter lesion,WML)患者中的應用.方法 納入WML患者,結閤影像學錶現和臨床癥狀分為皮質下動脈硬化性腦病(subcortical arteriosclerotic encephalopathy,SAE)組和單純腦白質疏鬆(leukoaraiosis,LA)組.所有病例均完成MRI、1 H-MRS和聽覺事件相關電位P300檢查.1 H-MRS多體素採集範圍為側腦室週圍白質區,記錄N-乙酰天鼕氨痠(N-acetylaspartate,NAA)、肌酐(creatine,Cr)、膽堿(choline,Cho)、NAA/Cr以及P300潛伏期和波幅.結果 共納入WML患者50例,其中SAE30例,單純LA 20例.SAE組NAA(中位數,四分位數間距;M,IQR)[0.732 (0.680 ～0.804)對0.915(0.866 ～ 0.963);Z=-5.634,P＜ 0.001]和NAA/Cr(M,IQR)[1.533(1.317～ 1.817)對2.003(1.794～2.387);Z=-3.921,P＜0.001]均較單純LA組顯著性降低.SAE組P300潛伏期(M,IQR)較單純LA組顯著延長[370.50(363.50 ～ 385.25)ms對351.50(342.75 ～ 359.00)ms;Z=-4.382,P＜ 0.001],且波幅(M,IQR)較單純LA組顯著性降低[4.35(2.90 ～7.20)mV對6.95(5.93 ～9.10)mV;Z=-2.942,P=0.003].結論 1 H-MRS可用于鑒彆SAE與單純LA患者,為預防LA進展為SAE提供客觀依據.
목적 탐토질자자공진파보(proton magnetic resonance spectroscopy,1H-MRS)재뇌백질병변(white matter lesion,WML)환자중적응용.방법 납입WML환자,결합영상학표현화림상증상분위피질하동맥경화성뇌병(subcortical arteriosclerotic encephalopathy,SAE)조화단순뇌백질소송(leukoaraiosis,LA)조.소유병례균완성MRI、1 H-MRS화은각사건상관전위P300검사.1 H-MRS다체소채집범위위측뇌실주위백질구,기록N-을선천동안산(N-acetylaspartate,NAA)、기항(creatine,Cr)、담감(choline,Cho)、NAA/Cr이급P300잠복기화파폭.결과 공납입WML환자50례,기중SAE30례,단순LA 20례.SAE조NAA(중위수,사분위수간거;M,IQR)[0.732 (0.680 ～0.804)대0.915(0.866 ～ 0.963);Z=-5.634,P＜ 0.001]화NAA/Cr(M,IQR)[1.533(1.317～ 1.817)대2.003(1.794～2.387);Z=-3.921,P＜0.001]균교단순LA조현저성강저.SAE조P300잠복기(M,IQR)교단순LA조현저연장[370.50(363.50 ～ 385.25)ms대351.50(342.75 ～ 359.00)ms;Z=-4.382,P＜ 0.001],차파폭(M,IQR)교단순LA조현저성강저[4.35(2.90 ～7.20)mV대6.95(5.93 ～9.10)mV;Z=-2.942,P=0.003].결론 1 H-MRS가용우감별SAE여단순LA환자,위예방LA진전위SAE제공객관의거.
Objective To investigate the application of proton magnetic resonance spectroscopy (1H-MRS) in patients with white matter lesions (WMLs).Methods Patients with WML were enrolled.According to imaging and clinical symptoms,they were divided into either a subcortical atherosclerotic encephalopathy (SAE) group or a simple leukoaraiosis (LA) group.All patients completed the examinations of MRI,1H-MRS,and auditory event-related potential P300.Multi-voxel 1H-MRS acquisition range was lateral periventricular white matter region.N-acetyl aspartic acid (N-acetylaspartate,NAA),creatinine (Cr),choline (Cho),NAA/Cr,and P300 latency and amplitude were documented.Results A total of 50 patients with WML were enrolled,including 30 patients with SAE and 20 with simple LA.NAA (median,quartile interval; M,IQR) (0.732 [0.680-0.804] vs.0.915 [0.866-0.963] ; Z =5.634,P ＜ 0.001) and NAA/Cr(M,IQR)(1.533 [1.317-1.817] vs.2.003 [1.794-2.387];Z=-3.921,P＜0.001) intheSAE group were significantly lower than those in the simple LA group.The htency of P300 (M,IQR) in the SAE group was significantly bnger than that in the LA group (370.50 [363.50-385.25] msvs.351.50 [342.75-359.00] ms; Z =-4.382,P ＜ 0.001),and the amplitude (M,IQR) was significantly lower than that in the simple LA group (4.35 [2.90-7.20] mVvs.6.95 [5.93-9.10] mV; Z=-2.942,P=0.003).Conclusions 1H-MRS can be used to identify the patients with SAE and simple LA,and provide an objective basis for the prevention of progress from LA to SAE.
