CAJ | 학술논문

组织型基质金属蛋白酶抑制是一种多功能的蛋白质,除了抑制基质金属蛋白酶活性外,还可通过调节细胞增殖、凋亡,以及血管生成参与恶性肿瘤的发生、侵袭和转移,近年来成为研究的热点.现已证实,组织型基质金属蛋白酶抑制对多种肿瘤发生起着促进和抑制的双向调节作用,这种双向调节作用在皮肤黑素瘤的研究中亦得到证实.进一步阐明,组织型基质金属蛋白酶抑制对恶性黑素瘤发生、侵袭、转移的关键作用,有望为恶性黑素瘤的治疗提供新思路、新靶点和新途径.
조직형기질금속단백매억제시일충다공능적단백질,제료억제기질금속단백매활성외,환가통과조절세포증식、조망,이급혈관생성삼여악성종류적발생、침습화전이,근년래성위연구적열점.현이증실,조직형기질금속단백매억제대다충종류발생기착촉진화억제적쌍향조절작용,저충쌍향조절작용재피부흑소류적연구중역득도증실.진일보천명,조직형기질금속단백매억제대악성흑소류발생、침습、전이적관건작용,유망위악성흑소류적치료제공신사로、신파점화신도경.
As a kind of multifunctional protein,tissue inhibitors of metalloproteinases (TIMPs) are well known for their ability to inhibit matrix metalloproteinase (MMP) activity.Besides,they can regulate cell proliferation,apoptosis,and angiogenesis through MMP-independent pathways.Due to the critical role in tumor initiation,invasion and metastasis,TIMPs have become a hotspot in cancer research.It has been evidenced that TIMPs have both inhibitory and stimulatory effect on tumorigenesis,and the paradoxical role has also been observed in melanoma.Better understanding of the crucial role of TIMPs in malignant melanoma may provide new ideas,targets and strategies for its treatment.