CAJ | 학술논문

患者男,59岁,因全身结节、斑块伴疼痛3个月就诊.皮肤科检查:躯干、四肢可见多个浸润性红色斑块和结节,压痛明显.皮损组织病理检查:真皮和皮下单一淋巴样细胞弥漫性浸润,核深染,染色质细如粉尘.免疫表型:肿瘤细胞CD20、CD79a、CD10、TdT、PAX5弥漫阳性,Ki-67增殖指数为70％.骨髓检查:骨髓增生活跃,以淋巴细胞异常增生为主,原幼淋占66％.诊断:皮肤B淋巴母细胞性淋巴瘤/白血病,诊断后转肿瘤科治疗.
환자남,59세,인전신결절、반괴반동통3개월취진.피부과검사:구간、사지가견다개침윤성홍색반괴화결절,압통명현.피손조직병리검사:진피화피하단일림파양세포미만성침윤,핵심염,염색질세여분진.면역표형:종류세포CD20、CD79a、CD10、TdT、PAX5미만양성,Ki-67증식지수위70％.골수검사:골수증생활약,이림파세포이상증생위주,원유림점66％.진단:피부B림파모세포성림파류/백혈병,진단후전종류과치료.
A 59-year-old man presented with a 3-month history of infiltrated aching nodules and plaques all over the body.Physical examination revealed multiple firm,erythematous nodules and plaques with marked tenderness on the trunk and limbs.Histopathological examination showed that there was a diffuse infiltrate of unique lymphoid cells with dark-stained nuclei and dust-like chromatin in the dermis and subdermis.Immunophenotype analysis showed that the tumor cells were diffusely positive for CD20,CD79a,CD10,terminal deoxynucleotidyl transferase (TdT),PAX5,and tor Ki-67 (70％).Bone marrow examination revealed an active proliferation of bone marrow cells,which were predominated by lymphocytes,with lymphoblasts and prolymphocytes accounting for 66％.The patient was diagnosed with cutaneous precursor B-cell lymphoblastic lymphoma/leukemia.