CAJ | 학술논문

患者男,56岁.2006年发现左前臂隆起性结节半年,渐增大.皮肤科检查:左前臂外侧可见一直径3 cm的肿物,其皮肤表面颜色略深,可见手术瘢痕长2.5 cm,肿物与皮肤粘连,固定,边界不清.组织病理学检查:瘤细胞圆形、卵圆形,小至中等大的淋巴母细胞,染色质细腻,核仁不明显,胞质少而淡染,弥漫分布.免疫组化:末端脱氧核苷酸转移酶(TDT)+、LCA+、CD20-、CD79a+、转录因子PAX5+、CD3-、CD30-、Ki-67阳性细胞数50％、上皮膜抗原(EMA)-、CD5-、CD10+、CD23-、CD56-.病理诊断:皮肤B淋巴母细胞淋巴瘤.治疗:给予环磷酰胺+多柔比星+长春新碱+泼尼松(CHOP)方案化疗,病情反复,随访4年9个月时患者死亡.
환자남,56세.2006년발현좌전비륭기성결절반년,점증대.피부과검사:좌전비외측가견일직경3 cm적종물,기피부표면안색략심,가견수술반흔장2.5 cm,종물여피부점련,고정,변계불청.조직병이학검사:류세포원형、란원형,소지중등대적림파모세포,염색질세니,핵인불명현,포질소이담염,미만분포.면역조화:말단탈양핵감산전이매(TDT)+、LCA+、CD20-、CD79a+、전록인자PAX5+、CD3-、CD30-、Ki-67양성세포수50％、상피막항원(EMA)-、CD5-、CD10+、CD23-、CD56-.병리진단:피부B림파모세포림파류.치료:급여배린선알+다유비성+장춘신감+발니송(CHOP)방안화료,병정반복,수방4년9개월시환자사망.
A 56-year old man developed a raised nodule on the left forearm half a year before 2006,which gradually enlarged.Skin examination revealed a mass measuring 3 cm in diameter at the extensor aspect of left forearm,which was fixed,slightly deep-colored,adherent to the skin with an unclear margin.There was a postoperative scar measuring 2.5 cm in length.Histopathological examination revealed small-to mediumsized round or oval lymphocytes with fine chromatin,unclear nucleoli,a small amount of lightly stained cytoplasm.Immunophenotype analysis showed that the tumor cells were positive for terminal deoxynucleotidyl transferase (TDT),leucocyte common antigen (LCA),PAX5 (paired box 5),C D79a,CD10,Ki-67 (50％),but negative for CD20,CD3,CD30,epithelial membrane antigen (EMA),CD5,CD23 and CD56.He was pathologically diagnosed with cutaneous B-cell lymphoblastic lymphoma,and given combination chemotherapy with cyclophosphamide,doxorubicin,vincristine and prednisone.Unfortunately,the condition was poorly controlled,and the patient died 4 years and 9 months later.