CAJ | 학술논문

DC-SIGN是一类表达在树突细胞上的C型凝集素受体,能识别和捕获多种糖基化抗原,与不同的糖基化配体及病原体作用可能参与不同的免疫调控.DC-SIGN为广谱的病原受体,与病毒、细菌及真菌等病原体相关,并参与慢性炎症及变态反应的过程,在皮肤科的作用越来越受到重视.DC-SIGN主要分布于外周组织不成熟DC以及淋巴组织成熟DC,最近发现亦表达于角质形成细胞、Schwann细胞.
DC-SIGN시일류표체재수돌세포상적C형응집소수체,능식별화포획다충당기화항원,여불동적당기화배체급병원체작용가능삼여불동적면역조공.DC-SIGN위엄보적병원수체,여병독、세균급진균등병원체상관,병삼여만성염증급변태반응적과정,재피부과적작용월래월수도중시.DC-SIGN주요분포우외주조직불성숙DC이급림파조직성숙DC,최근발현역표체우각질형성세포、Schwann세포.
Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) is a group of C-type lectin receptors specifically expressed on dendritic cells,which can recognize and capture many kinds of glycosylated antigens,and exert immunomodulatory effect through interaction with different carbohydrate ligands and pathogens.As the receptor of a broad-spectrum of pathogens,DC-SIGN is correlated with many pathogens such as virus,bacteria,fungi,and is involved in chronic inflammation and allergic reactions.Recently,more and more attention has been given to the roles of DC-SIGN in dermatoses and venereal diseases.DC-SIGN is mainly distributed on immature DCs in peripheral tissue and mature DCs in lymph tissues,and has also been observed on both keratinocytcs and Schwann cells recently.