CAJ | 학술논문

淋球菌是引起人类淋病的病原体,感染后可引起尿道炎、宫颈炎等.淋球菌对抗生素敏感,临床上常使用抗生素治疗淋球菌感染.随着抗生素的使用,淋球菌逐渐对青霉素类、四环素类、喹诺酮类药物产生耐药.目前头孢菌素类药物作为治疗淋球菌感染的一线药物,主要有头孢曲松和头孢克肟等.但引起人们高度关注的是,世界各地均有报道淋球菌对头孢菌素类药物的敏感性逐渐下降,特别是2010年分别在日本、法国和西班牙报道了“超级淋球菌”,因此,临床亟需寻找新的治疗方案.目前世界卫生组织提出各国应根据耐药监测数据制定适合本国淋球菌感染的治疗方案,主要是增加头孢曲松的剂量或者联合用药来治疗淋球菌感染.
림구균시인기인류임병적병원체,감염후가인기뇨도염、궁경염등.림구균대항생소민감,림상상상사용항생소치료림구균감염.수착항생소적사용,림구균축점대청매소류、사배소류、규낙동류약물산생내약.목전두포균소류약물작위치료림구균감염적일선약물,주요유두포곡송화두포극우등.단인기인문고도관주적시,세계각지균유보도림구균대두포균소류약물적민감성축점하강,특별시2010년분별재일본、법국화서반아보도료“초급림구균”,인차,림상극수심조신적치료방안.목전세계위생조직제출각국응근거내약감측수거제정괄합본국림구균감염적치료방안,주요시증가두포곡송적제량혹자연합용약래치료림구균감염.
As the cause of gonorrhea,Neissria gonorrhea (NG) can result in urethritis and cervicitis.NG infection is usually treated by antibiotics in clinical practice.With the wide use of antibiotics in the treatment of NG infection,there have been evidences for increasing resistance to penicillin,tetracycline and quinolones in NG.At present,cephalosporins,mainly including ceftriaxone and cefixime,are the first-line treatment of NG infection.Unfortunately,reducing sensitivity to cephalosporins has been reported in NG worldwide.In 2010,NG strains with high level of resistance to multiple antibiotics,also called NG superbug,were found in Japan,France and Spain.Hence,there is an urgent need to develop new strategies to control NG infection.The World Health Organization has proposed that individualized strategies should be developed for the treatment of NG infection according to surveillance results in different conntries.These strategies include increasing the dose of ceflriaxone,combining multiple drugs,etc.