CAJ | 학술논문

目的探讨大光斑、小功率Q开关Nd∶YAG激光联合谷胱甘肽、维生素C治疗黄褐斑的疗效和安全性.方法12例女性黄褐斑患者接受Medlite C6 Q开关Nd∶YAG激光,波长1064 nm,光斑6 mm,能量2.5～3.0 J/cm2,共治疗8次,间隔1周,第9次后治疗间隔改为1个月,共治疗6次.同时联合还原谷胱甘肽900 mg和维生素C2g静脉滴注,每天一次,共14 d为1个疗程,疗程间隔3个月.治疗前后均拍照,并算出治疗前后黄褐斑面积和严重指数(MASI).结果12例患者中治愈1例,显效5例,好转6例,无效0例.所有患者的平均MASI值由治疗前的13.8±4.3降到7.1±2.4(P＜ 0.05),差异有统计学意义.所有患者均无色素沉着和色素脱失等不良反应,治疗后患者毛孔缩小,皮肤更细腻.结论大光斑、小功率Q开关Nd∶YAG激光联合谷胱甘肽、维生素C治疗黄褐斑疗效好,安全性高,无需停工期,不良反应小,可作为治疗黄褐斑的一种选择.
목적탐토대광반、소공솔Q개관Nd∶YAG격광연합곡광감태、유생소C치료황갈반적료효화안전성.방법12례녀성황갈반환자접수Medlite C6 Q개관Nd∶YAG격광,파장1064 nm,광반6 mm,능량2.5～3.0 J/cm2,공치료8차,간격1주,제9차후치료간격개위1개월,공치료6차.동시연합환원곡광감태900 mg화유생소C2g정맥적주,매천일차,공14 d위1개료정,료정간격3개월.치료전후균박조,병산출치료전후황갈반면적화엄중지수(MASI).결과12례환자중치유1례,현효5례,호전6례,무효0례.소유환자적평균MASI치유치료전적13.8±4.3강도7.1±2.4(P＜ 0.05),차이유통계학의의.소유환자균무색소침착화색소탈실등불량반응,치료후환자모공축소,피부경세니.결론대광반、소공솔Q개관Nd∶YAG격광연합곡광감태、유생소C치료황갈반료효호,안전성고,무수정공기,불량반응소,가작위치료황갈반적일충선택.
Objective To evaluate the efficacy and safety of low-fluence and large spot-size 1064-nm Q-switched Nd∶YAG laser combined with glutathione hormone (GSH) and vitamin C for the treatment of melasma.Methods This study recruited 12 female melasma patients,with the age averaging (42.3 ± 6.56) years and varying from 32 to 56 years.The whole face with melasma lesions of all the patients were irradiated with 1064-nm Q-switched Nd∶YAG laser (Medlite C6) at fluences of 2.5-3.0 J/cm2 and a spot size of 6 mm for 8 sessions with an interval of 1 week followed by 6 sessions with an interval of 1 month.The patients also received 3 courses of 14-consecutive-day treatment with intravenous GSH 0.9 g and vitamin C 2 g once a day at a 3-month interval.Photographs were taken and melasma area and severity index (MASI) was calculated for the patients before and after the treatment.Results Of the 12 patients,1 was cured,5 markedly improved,6 improved,and all showed clinical response.The average MASI decreased from 13.8 ± 4.3 before treatment to 7.1 ± 2.4 after treatment (P＜ 0.05).Follicular orifices constricted and skin became smoother with no hypopigmentation or hyperpigmentation observed in the patients after the treatment.Conclusion The lowfluence,large spot-size,1064-nm Q-switched Nd ∶ YAG laser combined with GSH and vitamin C is a safe and effective treatment modality for melasma with no requirement for downtime.