国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2013年
4期
213-215
,共3页
崔华娟%李翠华%王卓才%赖日权%彭大云%陈敬文
崔華娟%李翠華%王卓纔%賴日權%彭大雲%陳敬文
최화연%리취화%왕탁재%뢰일권%팽대운%진경문
皮肤%肿瘤,鳞状细胞癌%血管肉瘤
皮膚%腫瘤,鱗狀細胞癌%血管肉瘤
피부%종류,린상세포암%혈관육류
Skin%Neoplasms,squamous cell%Hemangiosarcoma
目的 提高对易误诊为血管肉瘤的皮肤假血管肉瘤型鳞状细胞癌的认识.方法 报道2例皮肤原发的假血管肉瘤型鳞状细胞癌.结果 例1女性,71岁,皮损位于右小腿远端;例2男,57岁,皮损位于右颈部.皮损均为单发的溃疡性肿块.光镜下棘层显著松解形成假血管腔隙,内含游离肿瘤细胞和红细胞,腔隙内衬多角形或扁平、鞋钉样细胞.瘤细胞上皮样,异形性明显,核分裂象易见,胞质丰富,空泡状,核仁明显.肿瘤间质疏松,可见嗜碱性黏液样基质,局部区域弥漫出血坏死.免疫表型panCK、CK5/6、Vim、CK14、EMA、P63及P53阳性,血管内皮标记CD31、CD34、F8、Fli-1阴性.电镜下肿瘤胞质内存在少量的张力原纤维及典型的桥粒结构.结论 皮肤原发的假血管肉瘤型鳞状细胞癌是一种鳞状细胞癌亚型,需要与血管肉瘤、上皮样肉瘤等恶性肿瘤进行鉴别.
目的 提高對易誤診為血管肉瘤的皮膚假血管肉瘤型鱗狀細胞癌的認識.方法 報道2例皮膚原髮的假血管肉瘤型鱗狀細胞癌.結果 例1女性,71歲,皮損位于右小腿遠耑;例2男,57歲,皮損位于右頸部.皮損均為單髮的潰瘍性腫塊.光鏡下棘層顯著鬆解形成假血管腔隙,內含遊離腫瘤細胞和紅細胞,腔隙內襯多角形或扁平、鞋釘樣細胞.瘤細胞上皮樣,異形性明顯,覈分裂象易見,胞質豐富,空泡狀,覈仁明顯.腫瘤間質疏鬆,可見嗜堿性黏液樣基質,跼部區域瀰漫齣血壞死.免疫錶型panCK、CK5/6、Vim、CK14、EMA、P63及P53暘性,血管內皮標記CD31、CD34、F8、Fli-1陰性.電鏡下腫瘤胞質內存在少量的張力原纖維及典型的橋粒結構.結論 皮膚原髮的假血管肉瘤型鱗狀細胞癌是一種鱗狀細胞癌亞型,需要與血管肉瘤、上皮樣肉瘤等噁性腫瘤進行鑒彆.
목적 제고대역오진위혈관육류적피부가혈관육류형린상세포암적인식.방법 보도2례피부원발적가혈관육류형린상세포암.결과 례1녀성,71세,피손위우우소퇴원단;례2남,57세,피손위우우경부.피손균위단발적궤양성종괴.광경하극층현저송해형성가혈관강극,내함유리종류세포화홍세포,강극내츤다각형혹편평、혜정양세포.류세포상피양,이형성명현,핵분렬상역견,포질봉부,공포상,핵인명현.종류간질소송,가견기감성점액양기질,국부구역미만출혈배사.면역표형panCK、CK5/6、Vim、CK14、EMA、P63급P53양성,혈관내피표기CD31、CD34、F8、Fli-1음성.전경하종류포질내존재소량적장력원섬유급전형적교립결구.결론 피부원발적가혈관육류형린상세포암시일충린상세포암아형,수요여혈관육류、상피양육류등악성종류진행감별.
Objective To improve the knowledge on cutaneous pseudoangiosarcomatous squamous cell carcinoma (PASCC) which could be easily mistaken for angiosarcoma.Methods Two cases of uncommon primary PASCC were studied clinically,pathologically and immunohistochemically.Electron microscopy was also used to observe lesion specimens.Results The patients were a 71-year-old female and a 57-year-old male.A single ulcerative mass was observed on the right distal leg in the female patient and on the right neck in the male patient.Pathologically,acantholytic tumor cells formed lumina of pseudovascular spaces which contained dissociative tumor cells as well as erythrocytes and were lined by polygonal,flat or hobnailed cells.The tumor cells gave an epithelial appearance with obvious atypia,abundant vacuole-like cytoplasm and apparent nucleoli.Mitotic figures were easily seen.The stroma of tumor was loose,with basophilic mucinous matrix,diffuse necrosis and hemorrhage in some regions.Immunohistochemically,most tumor cells were strongly positive for panCK,CK5/6,Vim,CK14,epithelial membrane antigen (EMA),P63,and P53,but negative for CD31,CD34,F8,and Fli-1.Electron microscopy revealed a small quantity of tonofibrils and typical desmosomal structures in the cytoplasm of tumor cells.Conclusions Primary PASCC is a rare subtype of squamous cell carcinoma,and should be differentiated from angiosarcoma,epithelioid sarcoma,and so on.