CAJ | 학술논문

特应性皮炎是一种慢性复发性、炎症性皮肤疾病,病因复杂,涉及环境、基因及免疫之间的相互作用,其中免疫因素为特应性皮炎发病的重要原因之一.Th17作为一个不同于Th1和2的CD44T细胞亚群,已经证实,在特应性皮炎发生发展中起重要的作用.Th17通过分泌白介素-17、21、22等细胞因子诱发炎症反应及免疫反应,参与特应性皮炎发病的免疫学机制.通过物理治疗、药物治疗等手段,可以靶向抑制Th17及相关细胞因子,对治疗特应性皮炎有一定疗效.
특응성피염시일충만성복발성、염증성피부질병,병인복잡,섭급배경、기인급면역지간적상호작용,기중면역인소위특응성피염발병적중요원인지일.Th17작위일개불동우Th1화2적CD44T세포아군,이경증실,재특응성피염발생발전중기중요적작용.Th17통과분비백개소-17、21、22등세포인자유발염증반응급면역반응,삼여특응성피염발병적면역학궤제.통과물리치료、약물치료등수단,가이파향억제Th17급상관세포인자,대치료특응성피염유일정료효.
Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease.The etiology and pathogenesis of AD are complex,and may be associated with the interaction between environment,genes and immune system,among which,immunological factor appears to be the most important.As a newly identified CD4+ T cell subset,T helper type 17 (Thl7) cells are different from Th1 and Th2 cells,and have been demonstrated to play an important role in the initiation and progression of AD.It is considered that Th17 cells can induce inflammatory reaction and immunological reaction by secreting multiple cytokines such as interleukin (IL)-17,IL-21,IL-22,and so on.Further more,targeted inhibition of Th17 cells and related cytokines by using physical therapy and medication has shown favorable efficacy in the treatment of AD.