国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
3期
146-148
,共3页
赵玉磊%乐文静%朱晓凤%张津萍%尤永燕%龚向东%苏晓红
趙玉磊%樂文靜%硃曉鳳%張津萍%尤永燕%龔嚮東%囌曉紅
조옥뢰%악문정%주효봉%장진평%우영연%공향동%소효홍
梅毒%血清学%治疗结果%回顾性研究
梅毒%血清學%治療結果%迴顧性研究
매독%혈청학%치료결과%회고성연구
Syphilis%Serology%Treatment outcome%Retrospective studies
目的 探讨影响梅毒治疗后血清转归的相关因素.方法 回顾性研究226例HIV阴性梅毒患者的临床资料,观察驱梅治疗1年后血清痊愈或血清固定发生的情况,对影响血清固定的患者年龄、病期、性别、快速血浆反应素环状卡片试验(RPR)初始滴度、治疗用药等因素进行多因素Logistic分析.结果 226例患者中,154例(68.1％)血清痊愈,72例(31.9％)发生血清固定,随着病期延长,血清固定发生率增加.多因素Logistic分析结果显示,驱梅治疗后发生血清固定的因素包括:女性患者(OR=2.517,95％CI:1.159～5.464)、初始RPR滴度≤1:16(OR=4.370,95％ CI:1.311 ～ 14.562)和非苄星青霉素治疗(OR＝4.959,95％ CI:1.650～14.901),而与血清学痊愈相关的临床特征包括:一期梅毒和二期梅毒患者和年轻患者(≤25岁)(均P＜ 0.05).结论 梅毒治疗后血清学痊愈或固定与患者病期、性别、年龄、RPR基线滴度、治疗药物有关.
目的 探討影響梅毒治療後血清轉歸的相關因素.方法 迴顧性研究226例HIV陰性梅毒患者的臨床資料,觀察驅梅治療1年後血清痊愈或血清固定髮生的情況,對影響血清固定的患者年齡、病期、性彆、快速血漿反應素環狀卡片試驗(RPR)初始滴度、治療用藥等因素進行多因素Logistic分析.結果 226例患者中,154例(68.1％)血清痊愈,72例(31.9％)髮生血清固定,隨著病期延長,血清固定髮生率增加.多因素Logistic分析結果顯示,驅梅治療後髮生血清固定的因素包括:女性患者(OR=2.517,95％CI:1.159～5.464)、初始RPR滴度≤1:16(OR=4.370,95％ CI:1.311 ～ 14.562)和非芐星青黴素治療(OR＝4.959,95％ CI:1.650～14.901),而與血清學痊愈相關的臨床特徵包括:一期梅毒和二期梅毒患者和年輕患者(≤25歲)(均P＜ 0.05).結論 梅毒治療後血清學痊愈或固定與患者病期、性彆、年齡、RPR基線滴度、治療藥物有關.
목적 탐토영향매독치료후혈청전귀적상관인소.방법 회고성연구226례HIV음성매독환자적림상자료,관찰구매치료1년후혈청전유혹혈청고정발생적정황,대영향혈청고정적환자년령、병기、성별、쾌속혈장반응소배상잡편시험(RPR)초시적도、치료용약등인소진행다인소Logistic분석.결과 226례환자중,154례(68.1％)혈청전유,72례(31.9％)발생혈청고정,수착병기연장,혈청고정발생솔증가.다인소Logistic분석결과현시,구매치료후발생혈청고정적인소포괄:녀성환자(OR=2.517,95％CI:1.159～5.464)、초시RPR적도≤1:16(OR=4.370,95％ CI:1.311 ～ 14.562)화비변성청매소치료(OR＝4.959,95％ CI:1.650～14.901),이여혈청학전유상관적림상특정포괄:일기매독화이기매독환자화년경환자(≤25세)(균P＜ 0.05).결론 매독치료후혈청학전유혹고정여환자병기、성별、년령、RPR기선적도、치료약물유관.
Objective To identify factors predicting serological response in patients after syphilis treatment.Methods A retrospective study was performed on 226 human immunodeficiency virus (HIV)-negative patients with syphilis.Serological response was evaluated in these patients within one year after regular treatment of syphilis.A multivariate logistic regression analysis was conducted to identify possible factors associated with serological response,such as age,clinical stage,gender,initial rapid plasma regain (RPR) titer,administered drugs,and so on.Results One year after the recommended therapy,152 out of the 226 patients achieved a serological cure,and 73 (32.4％) remained in the serofast state.The serofast rate increased with clinical course.The multivariate logistic regression analysis indicated that female patients (OR =2.517,95％ CI:1.159-5.464),non-penicillin treatment (OR =4.959,95％ CI:1.650-14.901) and a baseline RPR titer ≤ 1:16 (OR =4.370,95％ CI:1.311-14.562) were associated with a higher serofast rate,while primary or secondary syphilis as well as young patients aged 25 years or less were associated with an increased likelihood of a serological cure (both P ＜ 0.05).Conclusion The serological response in patients after syphilis treatment is associated with clinical stage,gender,age,baseline RPR titer,and administered drugs.
