CAJ | 학술논문

副肿瘤性天疱疮是一种危及生命的自身免疫性大疱性疾病,由于其病程复杂、对药物反应具有不确定性,其治疗比较棘手.目前治疗主要针对副肿瘤天疱疮伴发的肿瘤和自身免疫反应.为此,根据副肿瘤天疱疮伴发的肿瘤良恶性不同,概述近几年副肿瘤天疱疮的治疗,包括使用糖皮质激素、免疫抑制剂、静脉滴注免疫球蛋白、血浆置换、外用他克莫司、应用生物制剂等的疗效.
부종류성천포창시일충위급생명적자신면역성대포성질병,유우기병정복잡、대약물반응구유불학정성,기치료비교극수.목전치료주요침대부종류천포창반발적종류화자신면역반응.위차,근거부종류천포창반발적종류량악성불동,개술근궤년부종류천포창적치료,포괄사용당피질격소、면역억제제、정맥적주면역구단백、혈장치환、외용타극막사、응용생물제제등적료효.
Paraneoplastic pemphigus (PNP) is a life-threatening autoimmune bullous disease.Due to its complex natural course and uncertain response to drugs,the treatment of PNP remains troublesome.The current treatment of PNP is mainly aimed at complicating tumors and autoimmune reactions.Based on the nature of tumors accompanying PNP,this paper describes recent advances in the treatment of PNP,including glucocorticoids,immunosuppressive agents,intravenous immunoglobulins,plasma exchange,topical tacrolimus,biological agents,etc.