国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
5期
309-312
,共4页
银屑病%遗传学%免疫%环境
銀屑病%遺傳學%免疫%環境
은설병%유전학%면역%배경
Psoriasis%Genetics%Immunology%Environment
关节病性银屑病和寻常性银屑病为银屑病的两个临床亚型,其临床表现上的差异可能与遗传、免疫及环境因素等相关.HLA-B、MICA*00801纯合子、CARD15、TNF*-857T、TRAF3IP2及IL-13等基因在关节病性银屑病患者中的频率较高;HLA-Cw*06、MICA*016、LCE等基因在寻常性银屑病患者中的频率较高.CD8+T细胞、TNF-α及IL-22在关节病性银屑病的关节损伤中起重要作用;CD4+T细胞、血管生长因子等与皮肤损害相关.感染、损伤、体力劳动等因素与关节病性银屑病患者发病相关性较高;吸烟、饮酒与关节病性银屑病的发病似乎呈负相关.
關節病性銀屑病和尋常性銀屑病為銀屑病的兩箇臨床亞型,其臨床錶現上的差異可能與遺傳、免疫及環境因素等相關.HLA-B、MICA*00801純閤子、CARD15、TNF*-857T、TRAF3IP2及IL-13等基因在關節病性銀屑病患者中的頻率較高;HLA-Cw*06、MICA*016、LCE等基因在尋常性銀屑病患者中的頻率較高.CD8+T細胞、TNF-α及IL-22在關節病性銀屑病的關節損傷中起重要作用;CD4+T細胞、血管生長因子等與皮膚損害相關.感染、損傷、體力勞動等因素與關節病性銀屑病患者髮病相關性較高;吸煙、飲酒與關節病性銀屑病的髮病似乎呈負相關.
관절병성은설병화심상성은설병위은설병적량개림상아형,기림상표현상적차이가능여유전、면역급배경인소등상관.HLA-B、MICA*00801순합자、CARD15、TNF*-857T、TRAF3IP2급IL-13등기인재관절병성은설병환자중적빈솔교고;HLA-Cw*06、MICA*016、LCE등기인재심상성은설병환자중적빈솔교고.CD8+T세포、TNF-α급IL-22재관절병성은설병적관절손상중기중요작용;CD4+T세포、혈관생장인자등여피부손해상관.감염、손상、체력노동등인소여관절병성은설병환자발병상관성교고;흡연、음주여관절병성은설병적발병사호정부상관.
Psoriasis vulgaris (PsV) and psoriatic arthritis (PsA) are two clinical types of psoriasis with distinct clinical manifestations.The difference in clinical presentations between the two types may be associated with genetic,immunological and environmental factors.HLA-B,MICA*00801 homozygote,CARD15,tumor necrosis factor (TNF)*-857T,TRAF3IP2 and interleukin (IL)-13 genes are more frequent,while HLA-Cw*06,MICA*016 and LCE genes are less frequent,in PsA patients than in PsV patients.CD8+ T cells,TNF-α and IL-22 play important roles in joint damage in PsA patients,while CD4+ T cells and vascular growth factors are associated with psoriatic skin lesions.Infection,injury and manual labor have a close relationship with the initiation of PsA,while smoking and drinking seem to be negatively associated with the occurrence of PsA.
