国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2014年
3期
219-221
,共3页
血小板配型%贫血,再生障碍性%血小板输注无效
血小闆配型%貧血,再生障礙性%血小闆輸註無效
혈소판배형%빈혈,재생장애성%혈소판수주무효
platelet cross-matched%anemia,aplastic%platelet transfusion refractory
目的 探讨再生障碍性贫血(AA)患者应用血小板配型前、后血小板输注效果及评价此技术的临床意义.方法 选择2012年4月至2013年8月,于中国人民解放军第二一○医院中医血液科住院的83例AA患者作为研究对象.按照血小板输注形式将其分为两组:采用血小板配型相合后再进行血小板输注的为研究组,共输注血小板108次;直接进行血小板输注的为对照组,共输注血小板118次.(本研究遵循的程序符合中国人民解放军第二一○医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书).统计学分析两组患者血小板计数增高指数(CCI)、血小板恢复百分率(PPR)以及血小板输注有效率之间的差异.两组患者在血小板输注前1h,其血小板计数比较,差异无统计学意义(P＞0.05).结果 研究组输注血小板1h、24 h后,其CCI与PPR均显著高于对照组,差异有统计学意义(P＜0.01).研究组血小板输注有效率亦显著高于对照组,差异有统计学意义(x2 =33.00,P＜0.01).结论 AA患者输注血小板前采用血小板配型技术,可有效避免血小板输注无效(PTR),提高血小板的输注效率,进而减少血液资源的浪费.
目的 探討再生障礙性貧血(AA)患者應用血小闆配型前、後血小闆輸註效果及評價此技術的臨床意義.方法 選擇2012年4月至2013年8月,于中國人民解放軍第二一○醫院中醫血液科住院的83例AA患者作為研究對象.按照血小闆輸註形式將其分為兩組:採用血小闆配型相閤後再進行血小闆輸註的為研究組,共輸註血小闆108次;直接進行血小闆輸註的為對照組,共輸註血小闆118次.(本研究遵循的程序符閤中國人民解放軍第二一○醫院人體試驗委員會所製定的倫理學標準,得到該委員會批準,分組徵得受試對象本人的知情同意,併與之籤署臨床研究知情同意書).統計學分析兩組患者血小闆計數增高指數(CCI)、血小闆恢複百分率(PPR)以及血小闆輸註有效率之間的差異.兩組患者在血小闆輸註前1h,其血小闆計數比較,差異無統計學意義(P＞0.05).結果 研究組輸註血小闆1h、24 h後,其CCI與PPR均顯著高于對照組,差異有統計學意義(P＜0.01).研究組血小闆輸註有效率亦顯著高于對照組,差異有統計學意義(x2 =33.00,P＜0.01).結論 AA患者輸註血小闆前採用血小闆配型技術,可有效避免血小闆輸註無效(PTR),提高血小闆的輸註效率,進而減少血液資源的浪費.
목적 탐토재생장애성빈혈(AA)환자응용혈소판배형전、후혈소판수주효과급평개차기술적림상의의.방법 선택2012년4월지2013년8월,우중국인민해방군제이일○의원중의혈액과주원적83례AA환자작위연구대상.안조혈소판수주형식장기분위량조:채용혈소판배형상합후재진행혈소판수주적위연구조,공수주혈소판108차;직접진행혈소판수주적위대조조,공수주혈소판118차.(본연구준순적정서부합중국인민해방군제이일○의원인체시험위원회소제정적윤리학표준,득도해위원회비준,분조정득수시대상본인적지정동의,병여지첨서림상연구지정동의서).통계학분석량조환자혈소판계수증고지수(CCI)、혈소판회복백분솔(PPR)이급혈소판수주유효솔지간적차이.량조환자재혈소판수주전1h,기혈소판계수비교,차이무통계학의의(P＞0.05).결과 연구조수주혈소판1h、24 h후,기CCI여PPR균현저고우대조조,차이유통계학의의(P＜0.01).연구조혈소판수주유효솔역현저고우대조조,차이유통계학의의(x2 =33.00,P＜0.01).결론 AA환자수주혈소판전채용혈소판배형기술,가유효피면혈소판수주무효(PTR),제고혈소판적수주효솔,진이감소혈액자원적낭비.
Objective To assess the efficiency of platelets transfusion after platelet cross-matched and evaluate the clinical value in patients with aplasfic anemia.Methods From April 2012 to August 2013,a total of 83 cases of aplasfic anemia patients in department of traditional chinese medicine & hematology,210th Hospital of People's Liberation Army were selected in the study.According to the platelet transfusion form,the 83 cases of aplasfic anemia patients were divided into study group (using platelet cross-matched before transfusing platelets) which transfused plates 108 times in all and control group (directly tranfusing platelets without cross-matched) which transfused plates 118 times in all.The study protocol was approved by the Ethical Review Board of Investigation in 210th Hospital of People's Liberation Army.Informed consent was obtained from all participants.Compare the differences of corrected count increment (CCI),percentage platelet recovery (PPR) and platelet transfusion efficiency between the two groups.1 h before platelet transfusion,the platelet count of the two group had no statistical significance (P ＞ 0.05).Results 1 h and 24 h after platelet transfusion,the CCI and PPR of study group were higher than control group (P＜0.01).And the platelet transfusion efficiency of study group was also higher than control group (x2 =33.00,P＜0.01).Conclusions The application of platelet cross-matched can effectively avoid platelet refractoriness in patients with aplastic anemia and improve the efficiency of platelet transfusion,thereby reducing the waste of blood resources.
