CAJ | 학술논문

肿瘤的侵袭转移是恶性肿瘤患者治疗失败和死亡的主要原因.肿瘤转移的机制至今未明,而肿瘤的转移前微环境假说为认识肿瘤的转移机制提供了新的思路.在该假说中,骨髓源性细胞、微泡、外分泌体、CD44等多种因素在前微环境的形成过程中都发挥了重要作用.对肿瘤转移前微环境假说的深入研究有助于我们理解肿瘤转移的本质,为肿瘤的临床诊断和靶向治疗提供新的策略.
종류적침습전이시악성종류환자치료실패화사망적주요원인.종류전이적궤제지금미명,이종류적전이전미배경가설위인식종류적전이궤제제공료신적사로.재해가설중,골수원성세포、미포、외분비체、CD44등다충인소재전미배경적형성과정중도발휘료중요작용.대종류전이전미배경가설적심입연구유조우아문리해종류전이적본질,위종류적림상진단화파향치료제공신적책략.
Tumor invasion and metastasis are regarded as main reasons for the failure of therpy and the reason of patients death.The mechnism of tumor metastasis is still uncertain.The pre-metastatic niche hypothesis provides us with new ideas to discover the mechnism.Numerous materials are involved in the formation of the pre-metastatic niche according to this hypothesis,including bone marrow-derived cells,microvesicles,exosomes,CD44,and so on.A further research on this hypothesis helps to deeply understand the nature of metastasis and leads clinical doctors to explore novel targets for clinical diagnoses and therapies.