CAJ | 학술논문

目的研究趋化因子受体4(CXCR4)与上皮间质转化(EMT)相关因子Snail表达与胃癌临床病理特征、预后的关系.方法利用免疫组化方法检测50例胃癌组织中CXCR4和Snail的表达,分析Snail和CXCR4表达与胃癌患者的临床病理学指标的关系,Spearman等级相关方法分析Snail和CXCR4表达的关系,Kaplan-Meier方法分析CXCR4和Snail表达与胃癌患者生存的关系.结果 Snail和CXCR4表达阳性率各为62％ (31/50)和58％ (29/50)；肿瘤越大、组织分化越差、有血管浸润、淋巴管浸润、存在淋巴结转移和浸润越深Snail阳性表达越高.肿瘤越大、有血管浸润、有淋巴管浸润、存在淋巴结转移和浸润越深,则CXCR4阳性表达越高.Spearman相关分析表明,Snail与CX-CR4的表达呈正相关(r=0.330,P=0.014).Snail和CXCR4共同阳性表达为患者术后生存的独立预后因素(P=O.001).结论 CXCR4和Snail共同表达为胃癌患者独立预后因子,两者之间可能互相联系促进胃癌的侵袭和转移,通过靶向CXCR4和EMT相关因子或能干预胃癌的转移与复发.
목적 연구추화인자수체4(CXCR4)여상피간질전화(EMT)상관인자Snail표체여위암림상병리특정、예후적관계.방법 이용면역조화방법검측50례위암조직중CXCR4화Snail적표체,분석Snail화CXCR4표체여위암환자적림상병이학지표적관계,Spearman등급상관방법분석Snail화CXCR4표체적관계,Kaplan-Meier방법분석CXCR4화Snail표체여위암환자생존적관계.결과 Snail화CXCR4표체양성솔각위62％ (31/50)화58％ (29/50)；종류월대、조직분화월차、유혈관침윤、림파관침윤、존재림파결전이화침윤월심Snail양성표체월고.종류월대、유혈관침윤、유림파관침윤、존재림파결전이화침윤월심,칙CXCR4양성표체월고.Spearman상관분석표명,Snail여CX-CR4적표체정정상관(r=0.330,P=0.014).Snail화CXCR4공동양성표체위환자술후생존적독립예후인소(P=O.001).결론 CXCR4화Snail공동표체위위암환자독립예후인자,량자지간가능호상련계촉진위암적침습화전이,통과파향CXCR4화EMT상관인자혹능간예위암적전이여복발.
Objective To investigate the clinicopathologic characters and prognostic value of epithelial mesenchymal transition (EMT) related proteins Snail and chemokine receptors 4(CXCR4) in gastric cancer.Methods The expressions of Snail and CXCR4 in the gastric tissues of 50 patients with gastric cancer were detected by Immunohistochemistry.The relation between the expressions of Snail and CXCR4 and the clinicopathologic characters were analyzed.The relative relationship between Snail expression and CXCR4 expression were identified by Spearman method.The correlation between the expressions of Snail and CXCR4 with the survival was analyzed by Kaplan-Meier method.Results The expression of Snail and CXCR4 expression were positive in 31 of 50 cases (62％) and 29 of 50 cases (58％) respectively.The expression levels of Snail and CXCR4 in the gastric cancer patients with diameter more than 5 cm,worse tissue differentiation,vascular invasion,lymphatic vessel invasion,lymph nodes metastasis,and T3 + T4 staging were significantly higher than those in the patients with diameter less than 5 cm,without vascular invasion,lymphatic vessel invasion,lymph nodes metastasis,and T1 + T2 staging (P ＜ 0.05).The Expression of Snail and CXCR4 was positively Correlated(r =0.330,P =0.014).The co-expression of Snail and CXCR4 was significantly associated with poorer prognosis and was applied as an independent prognostic factor for gastric cancer (P =0.001).Conclusions The co-expression of Snail and CXCR4 was the independent prognostic factor for gastric cancer.The combining effect of EMT and CXCR4 may promote the progressions and metastasis of gastric cancer.Therefore,it may be of an effective way for the metastasis of gastric cancer to adjust these targets of the Snail and CXCR4.