CAJ | 학술논문

多功能蛋白聚糖来自成纤维细胞,属于软骨素蛋白聚糖,分布在多种组织中.多功能蛋白聚糖具有调节细胞生长、分化,促进细胞增生、侵袭、转移,促进血管发生的功能.实验证实多功能蛋白聚糖的表达参与多种肿瘤的发生、发展.本文就多功能蛋白聚糖与乳腺癌、肝癌以及软骨肉瘤的发生、发展关系作一综述,以进一步探求肿瘤的发病机制.
다공능단백취당래자성섬유세포,속우연골소단백취당,분포재다충조직중.다공능단백취당구유조절세포생장、분화,촉진세포증생、침습、전이,촉진혈관발생적공능.실험증실다공능단백취당적표체삼여다충종류적발생、발전.본문취다공능단백취당여유선암、간암이급연골육류적발생、발전관계작일종술,이진일보탐구종류적발병궤제.
Versican comes from fibroblasts and belongs to chondroitin sulfate proteoglycan.It distributes in various tissues.The versican have functions including regulate cell growth and differentiation,promote cell proliferation,invasion and metastasis,and stimulate angiogenesis.Experiments have confirmed that the expression of versican is involved in various cancers.Here,the author do an overview of versican in the occurrence and development of breast cancer,liver cancer and chondrosarcoma aimed to further explore the pathogenesis of tumors.