国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2013年
7期
489-492
,共4页
糖代谢%糖酵解%Micro RNAs%肿瘤
糖代謝%糖酵解%Micro RNAs%腫瘤
당대사%당효해%Micro RNAs%종류
Glucose Metabolism%Glycolysis%MicroRNAs%Neoplasms
有氧糖酵解(Warburg效应)是肿瘤细胞的重要特征,它是癌基因和抑癌基因共同作用的结果.microRNA (miRNA)能够在转录后水平参与这些癌基因和抑癌基因的表达来调控肿瘤糖代谢方式的转变.对miRNA调控糖代谢机制的深入研究能够提供新的肿瘤治疗策略.
有氧糖酵解(Warburg效應)是腫瘤細胞的重要特徵,它是癌基因和抑癌基因共同作用的結果.microRNA (miRNA)能夠在轉錄後水平參與這些癌基因和抑癌基因的錶達來調控腫瘤糖代謝方式的轉變.對miRNA調控糖代謝機製的深入研究能夠提供新的腫瘤治療策略.
유양당효해(Warburg효응)시종류세포적중요특정,타시암기인화억암기인공동작용적결과.microRNA (miRNA)능구재전록후수평삼여저사암기인화억암기인적표체래조공종류당대사방식적전변.대miRNA조공당대사궤제적심입연구능구제공신적종류치료책략.
Aerobic glycolysis,which is also termed as Warburg effect,is one of the most common and profound biochemical phenotypes of tumor ceils.Several oncogenes and tumor suppressors genes have been implicated in aerobic glycolysis.MicroRNAs can control this metabolic switch by regulating oncogenes and tumor suppressors genes in a post-transcriptional way.A deeper understanding of the mechanisms and pathways by which miRNAs regulate the aerobic glycolysis will hopefully lead to a new therapeutic strategy for malignant cancer.
