CAJ | 학술논문

凋亡抑制因子Livin是凋亡抑制蛋白家族的新成员.Livin在多种肿瘤组织中高表达,在细胞凋亡、细胞增生、细胞周期调控及参与肿瘤血管生成等过程中发挥重要作用,并且与化疗耐药性相关.大量研究表明,在许多恶性肿瘤组织中Livin异常表达与患者的预后密切相关,如肿瘤复发、生存期较短等.因此,以Livin为靶点的基因与免疫治疗也成为热点研究之一,为肿瘤的综合治疗提供了新的策略和方向.
조망억제인자Livin시조망억제단백가족적신성원.Livin재다충종류조직중고표체,재세포조망、세포증생、세포주기조공급삼여종류혈관생성등과정중발휘중요작용,병차여화료내약성상관.대량연구표명,재허다악성종류조직중Livin이상표체여환자적예후밀절상관,여종류복발、생존기교단등.인차,이Livin위파점적기인여면역치료야성위열점연구지일,위종류적종합치료제공료신적책략화방향.
Livin,as a novel member of human inhibitor of apoptosis protein family,is highly expressed in many malignant tumors.Livin plays critical role in apoptosis inhibition,regulating the cell cycle,participating in tumor angiogenesis.Livin is also significant to chemoresistance.The majority of the current data suggests that Livin expression in cancer appears to be associated with unfavorable clinico-pathological parameters,such as disease relapse and shorter patient survival.In recent years,immunotherapy and gene therapy for the targeting of Livin have become a hot research field,which provides new strategy and direction for tumor therapy.