国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2014年
5期
315-318
,共4页
张豪云%巩涛%王跃欣%宁殿宾%曹文庆%张旺%秦莉
張豪雲%鞏濤%王躍訢%寧殿賓%曹文慶%張旺%秦莉
장호운%공도%왕약흔%저전빈%조문경%장왕%진리
短期甲减%血脂%阿托伐他汀%甲状腺近全切除术%131I%兔%手术前期%手术后期间
短期甲減%血脂%阿託伐他汀%甲狀腺近全切除術%131I%兔%手術前期%手術後期間
단기갑감%혈지%아탁벌타정%갑상선근전절제술%131I%토%수술전기%수술후기간
Short-term hypothyroidism%Lipid%Atorvastatin%Near-total thyroidectomy%131I%Rabbits%Preoperative period%Postoperative period
目的 观察短期甲减对血脂水平的影响及阿托伐他汀的保护作用.方法 新西兰大白兔60只,随机分成实验组1(甲状腺近全切除+ 131I清甲n=20)、实验组2(甲状腺近全切除+131 I清甲+阿托伐他汀干预n=20)、对照组(假甲状腺切除组n=20).比较各组术前、术后3周和术后5周甲状腺功能和血脂水平变化.结果 (1)与术前相比,两实验组甲状腺功能在术后3周和术后5周均明显降低;(2)手术后随时间延长实验组1 TG、TC、LDL-C水平逐渐升高;术后5周实验组1 HDL-C水平与术前相比明显降低.术后3周和术后5周实验组2 TG水平较术前明显降低;术后3周实验组2 LDL-C水平较术前明显降低.结论 (1)短期甲减可以使血浆TG、TC、LDL-C水平升高;(2)阿托伐他汀可维持短期甲减期间血脂稳定.
目的 觀察短期甲減對血脂水平的影響及阿託伐他汀的保護作用.方法 新西蘭大白兔60隻,隨機分成實驗組1(甲狀腺近全切除+ 131I清甲n=20)、實驗組2(甲狀腺近全切除+131 I清甲+阿託伐他汀榦預n=20)、對照組(假甲狀腺切除組n=20).比較各組術前、術後3週和術後5週甲狀腺功能和血脂水平變化.結果 (1)與術前相比,兩實驗組甲狀腺功能在術後3週和術後5週均明顯降低;(2)手術後隨時間延長實驗組1 TG、TC、LDL-C水平逐漸升高;術後5週實驗組1 HDL-C水平與術前相比明顯降低.術後3週和術後5週實驗組2 TG水平較術前明顯降低;術後3週實驗組2 LDL-C水平較術前明顯降低.結論 (1)短期甲減可以使血漿TG、TC、LDL-C水平升高;(2)阿託伐他汀可維持短期甲減期間血脂穩定.
목적 관찰단기갑감대혈지수평적영향급아탁벌타정적보호작용.방법 신서란대백토60지,수궤분성실험조1(갑상선근전절제+ 131I청갑n=20)、실험조2(갑상선근전절제+131 I청갑+아탁벌타정간예n=20)、대조조(가갑상선절제조n=20).비교각조술전、술후3주화술후5주갑상선공능화혈지수평변화.결과 (1)여술전상비,량실험조갑상선공능재술후3주화술후5주균명현강저;(2)수술후수시간연장실험조1 TG、TC、LDL-C수평축점승고;술후5주실험조1 HDL-C수평여술전상비명현강저.술후3주화술후5주실험조2 TG수평교술전명현강저;술후3주실험조2 LDL-C수평교술전명현강저.결론 (1)단기갑감가이사혈장TG、TC、LDL-C수평승고;(2)아탁벌타정가유지단기갑감기간혈지은정.
Objective To observe the effects of short-term withdrawal of thyroxine on lipid level and the protective effect of atorvastatin.Methods The study included 60 rabbits which were randomly divided into treatment experiment group 1 (near-total thyroidectomy + 131 I ablative therapy),treatment experiment group 2 (near-total thyroidectomy + 131I ablative therapy + Atorvastatin intervention) and control group(sham thyroidectomy).Compared the thyroid functions and lipid levels among different groups at the points of before surgery.three weeks after surgery and five weeks after surgery.Results (1) Compared to before surgery,the thyroid function at the points of three weeks and five weeks after surgery were obvious reduced both in treatment group.(2) The leves of TG,TC,LDL-C in EG1 were increased gradually with the extension of time after surgery.Compared with the point of before surgery,the level of HDL-C at the point of five weeks after surgery was significantly declined in EG1.Compared with the point of before surgery,the level of TG at the ponts of three weeks and five weeks after surgery was significantly declined in EG2.Compared with the point of before surgery,the level of LDL-C at the point of three weeks after surgery was significantly declined in EG2.Conclusions (1) Short-term hypothyroidism can increase the levels of TG,TC,LDL-C in plasma.(2) Atorvastatin can maintain the stability of blood lipids during Short-term hypothyroidism.
