CAJ | 학술논문

结肠癌转移相关基因-1(MACC1)是新近发现的一个与结肠癌密切相关的基因,研究表明,MACC1与多种恶性肿瘤的转移和复发有密切的相关性,可能在肿瘤转移的共同通路中起着至关重要的调控作用.本研究就MACC1在结肠癌、肝癌、胃癌、肺癌、卵巢癌和乳腺癌等多种恶性肿瘤中的表达与功能调控等方面进行综述,以期为肿瘤转移调控的靶向治疗提供一个新的方向.
결장암전이상관기인-1(MACC1)시신근발현적일개여결장암밀절상관적기인,연구표명,MACC1여다충악성종류적전이화복발유밀절적상관성,가능재종류전이적공동통로중기착지관중요적조공작용.본연구취MACC1재결장암、간암、위암、폐암、란소암화유선암등다충악성종류중적표체여공능조공등방면진행종술,이기위종류전이조공적파향치료제공일개신적방향.
Metastasis-associated in colon cancer-1 (MACC1) is a recently discovered gene associated with colon cancer metastasis,there is significant relationship indicated from some studies between MACC1 and different malignant tumors.It may play an important role in the regulation of tumors metastasis.This article reviewed the expression and regulating function of MACC1 in different cancers including colorectal cancer,hepatic cancer,gastric cancer,lung cancer,ovarian cancer,breast cancer,and so on.It may offer clues to find a new target for target treatment of cancer metastasis.