CAJ | 학술논문

长链非编码RNA是一类长度大于200个核苷酸的不编码任何蛋白质的核糖核酸分子.长链非编码RNA虽然不编码任何蛋白质,但其通过染色质修饰,转录激活与干扰等参与了细胞内多种调控过程.近年来研究发现,在胃癌中多种长链非编码RNA的表达出现异常.这些异常改变与胃癌的发生、发展及预后密切相关,调控相关长链非编码RNA的表达可显著改善患者的预后.靶向调控长链非编码RNA的表达可为胃癌治疗提供新的策略.
장련비편마RNA시일류장도대우200개핵감산적불편마임하단백질적핵당핵산분자.장련비편마RNA수연불편마임하단백질,단기통과염색질수식,전록격활여간우등삼여료세포내다충조공과정.근년래연구발현,재위암중다충장련비편마RNA적표체출현이상.저사이상개변여위암적발생、발전급예후밀절상관,조공상관장련비편마RNA적표체가현저개선환자적예후.파향조공장련비편마RNA적표체가위위암치료제공신적책략.
Long non-coding RNA (LncRNA) is a kind of length greater than 200 nucleotides not encode any proteins RNA molecules.Although not encode any proteins,LncRNA through chromatin modification,transcription activation and interference et al.involved in a variety of control process in the cell.In recent years,the study found that the expression of a variety of LncRNA abnormalities in gastric cancer.These changes are closely associated with the development and prognosis of gastric cancer,regulate the expression of related LncRNA can significantly improve the prognosis of patients.Targeted to regulate the expression of LncRNA can provide new strategies for treatment of gastric cancer.