CAJ | 학술논문

人类肿瘤的发生是由于细胞生长和死亡的不平衡导致的.控制这个平衡的关键是调节细胞周期的蛋白.目前发现的与密切调节细胞周期特定阶段效应分子包括细胞周期蛋白,细胞周期蛋白依赖性激酶(cyclin-dependent kinases CDKs)和CDK抑制因子.G1期检测点的CDK抑制因子-p21(CDKN1 A)和p27(CDKN1 B)影响许多恶性肿瘤的发生发展.越来越多的证据表明p21或p27功能的缺失可以促进耐药.而另外一些实验证明p21和p27能促进肿瘤的发生发展.在本文中,我们将讨论这两个CDK抑制因子的功能,在肿瘤发生机制以及在耐药性中的作用.
인류종류적발생시유우세포생장화사망적불평형도치적.공제저개평형적관건시조절세포주기적단백.목전발현적여밀절조절세포주기특정계단효응분자포괄세포주기단백,세포주기단백의뢰성격매(cyclin-dependent kinases CDKs)화CDK억제인자.G1기검측점적CDK억제인자-p21(CDKN1 A)화p27(CDKN1 B)영향허다악성종류적발생발전.월래월다적증거표명p21혹p27공능적결실가이촉진내약.이령외일사실험증명p21화p27능촉진종류적발생발전.재본문중,아문장토론저량개CDK억제인자적공능,재종류발생궤제이급재내약성중적작용.
Human cancers arise from an imbalance of cell growth and cell death.Critical factors that control the balance are those regulate the cell cycle.Several molecular effectors have been identified to be able to regulate specific phases of the cell cycle,including cyclins,cyclin-dependent kinases (CDKs) and CDK inhibitors.Notably,deficiency of two G1-checkpoint CDK inhibitors-p21 (CDKN1A) and p27 (CDKN1B)-has been implicated to be correlated with initiation or progression of many human malignancies or cancer cells drug-resistance.However,contradict reports also suggested that p21 and p27 could promote tumor progression.Here,we summarized the historic and recent studies on these two CDK inhibitors,including their identification as well as their roles in carcinogenesis and drug resistance.