CAJ | 학술논문

目的探讨125I放射性粒子植入治疗晚期胰腺癌的临床效果.方法选择无外科根治性手术适应证的胰腺癌患者26例,开腹行125I放射性粒子植入术,胆肠Rou-en-y吻合术.术后观察:(1)术后胆红素下降情况;(2)术后1周内每日患者疼痛的缓解情况;(3)术后并发症发生情况.随访观察肿瘤变化、疼痛缓解程度以及存活期.结果 (1)术后1周内胆红素值降至术前一半的占52.3％(11/21),以后胆红素继续缓慢下降,所有患者均在3周内降至正常;(2)术后1周94.7％的患者疼痛缓解,平均缓解时间为(5.0±1.5)d.18例(69.2％)术后出现胃肠功能紊乱,6例出现胃瘫(23％),平均治愈时间为(16±5.1)d.胰漏3例经保守治疗痊愈,24例患者进行术后随访,平均生存期(12±5.1)个月,肿瘤较术前有缩小9例(37.5％),肿瘤无明显增大10例(41.6％),肿瘤明显增大5例(20.8％).结论 125I放射性粒子植入可有效改善晚期胰腺癌症状,一定程度上抑制肿瘤,是晚期胰腺癌有效治疗方法之一.
목적 탐토125I방사성입자식입치료만기이선암적림상효과.방법 선택무외과근치성수술괄응증적이선암환자26례,개복행125I방사성입자식입술,담장Rou-en-y문합술.술후관찰:(1)술후담홍소하강정황;(2)술후1주내매일환자동통적완해정황;(3)술후병발증발생정황.수방관찰종류변화、동통완해정도이급존활기.결과 (1)술후1주내담홍소치강지술전일반적점52.3％(11/21),이후담홍소계속완만하강,소유환자균재3주내강지정상;(2)술후1주94.7％적환자동통완해,평균완해시간위(5.0±1.5)d.18례(69.2％)술후출현위장공능문란,6례출현위탄(23％),평균치유시간위(16±5.1)d.이루3례경보수치료전유,24례환자진행술후수방,평균생존기(12±5.1)개월,종류교술전유축소9례(37.5％),종류무명현증대10례(41.6％),종류명현증대5례(20.8％).결론 125I방사성입자식입가유효개선만기이선암증상,일정정도상억제종류,시만기이선암유효치료방법지일.
Objective To investigate the effect of iodine-125 seed implantation in the treatment of unresectable pancreatic carcinoma.Methods A total of 26 pancreatic carcinoma patients were retrospectively analyzed.Patients undergoing palliative operation in combination with iodine-125 seed implantation.jundice recovery,objective tumor response,pain relieved,clinical benefit response,median survival time and complication were investigated.Results Half of cases with jundice has reduced and totally normal in 3 weeks.Abdominal pain was relieved in 94.7％ patients,average recovery duration was (5.0 ± 1.5) d.18 cases had gastroenterol function disorder (69.2％),gastroparesis in six cases (23％) and average recover time was (16 ± 5.1) d.24 of 26 cases were follow up study,median survival time was (12 ± 5.1) months,objective tumor response was smaller than preoperation in 9,no change in 10 and 5 cases became larger than before.Conclusions Palliative operation in combination with iodine-125 seed implantation is safe and effective in the treatment of unresectable pancreatic carcinoma.