NF-κB信号通路在胰腺癌转移调控中的作用机制
NF-κB신호통로재이선암전이조공중적작용궤제
Roles of NF-κB signaling pathway in regulatory network of pancreatic cancer metastasis
  • 万方数据
    国际外科学杂志 국제외과학잡지
    INTERNATIONAL JOURNAL OF SURGERY
    2014年 9期 622-625 ,共4页

    杜永星%由磊%任晓霞%刘子文%赵玉沛

    두영성%유뢰%임효하%류자문%조옥패

    NF-κB%胰腺肿瘤%肿瘤转移%分子靶向治疗 NF-κB%胰腺腫瘤%腫瘤轉移%分子靶嚮治療
    NF-κB%이선종류%종류전이%분자파향치료
    NF-kappa B%Pancreatic neoplasms%Neoplasm metastasis%Molecular targeted therapy
    胰腺癌是恶性程度较高的肿瘤之一,绝大多数患者最终死于其广泛转移.多种基因介导的细胞信号通路参与了胰腺癌侵袭和转移的调控.核因子-κB是其中关键的调控通路之一.研究发现,核因子-κB通路对细胞增生、凋亡抵抗、血管形成、上皮间质转化、炎症反应和应激反应等一系列与转移相关的生物学过程具有重要的调控作用,并且可以上调Hedgehog、MMPs等介导转移的信号通路,为临床医师更好地理解胰腺癌转移的调控机制,进一步寻找高敏感性的肿瘤标志物及选择性强的治疗靶点提供了新的思路.
    이선암시악성정도교고적종류지일,절대다수환자최종사우기엄범전이.다충기인개도적세포신호통로삼여료이선암침습화전이적조공.핵인자-κB시기중관건적조공통로지일.연구발현,핵인자-κB통로대세포증생、조망저항、혈관형성、상피간질전화、염증반응화응격반응등일계렬여전이상관적생물학과정구유중요적조공작용,병차가이상조Hedgehog、MMPs등개도전이적신호통로,위림상의사경호지리해이선암전이적조공궤제,진일보심조고민감성적종류표지물급선택성강적치료파점제공료신적사로.
    Pancreatic cancer is one of the most malignant tumors with a high mortality rate attributed to its widespread metastasis.A number of cellular signal transduction pathways involved in multiple genes play an important role in regulating this complex metastatic cascade of pancreatic cancer.NF-kappa B is one of the crucial signaling pathways.Studies has indicated that NF-kappa B could modulate a series of biological events relevant to tumor progress by controlling multiple targeted genes expression,such as cell proliferation,anti-apoptosis,angiogenesis,epithelial-mesenchymal transition,inflammation,stress response,etc.Furthermore,it can also up-regulate Hedgehog and MMPs signaling pathways.To help us better understand the potential mechanism and identify more sensitive tumor markers and selective targets,this review will underline the significant roles of NF-kappa B signaling pathway in regulatory network of pancreatic cancer metastasis.
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